Registration Dossier

Diss Factsheets

Ecotoxicological information

Long-term toxicity to fish

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
fish early-life stage toxicity
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
1. SOFTWARE: ECOSAR v2.2
2. MODEL: Estimation of Toxicity to Aquatic Organisms Using ECOSAR v2.2: Chemical Class: Amides: Fish Chronic value (ChV)
3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL: CC(C(=O)N(C)C)O
4. SCIENTIFIC VALIDITY OF THE MODEL: see attached documents
5. APPLICABILITY DOMAIN: see attached documents
Qualifier:
no guideline followed
Principles of method if other than guideline:
- Software tool(s) used including version: ECOSAR v2.2
- Model(s) used: Estimation of Toxicity to Aquatic Organisms Using ECOSAR v2.2: Chemical Class: Amides: Fish Chronic Value
- Model description: see field 'Justification for non-standard information', 'Attached justification' and/or 'Cross-reference'
GLP compliance:
no
Remarks:
predicted data
Analytical monitoring:
not required
Details on sampling:
not applicable
Vehicle:
no
Test organisms (species):
other: Different freshwater fish species
Test type:
other: QSAR prediction
Water media type:
freshwater
Key result
Duration:
30 d
Dose descriptor:
NOEC
Remarks:
proxy derived by dividing ChV by √2.
Effect conc.:
16.4 mg/L
Remarks on result:
other: A proxy to derive the NOEC is to divide the ChV by √2 (ECHA Practical guide on How to use and report (Q)SARs, version 3.1, 2016).
Duration:
30 d
Dose descriptor:
other: ChV (chronic value)
Effect conc.:
23.2 mg/L
Remarks on result:
ChV (chronic value, QSAR)
Remarks:
The chronic value (ChV) is defined as the geometric mean of the no observed effect concentration (NOEC) and the lowest observed effect concentration (LOEC) (ECHA Practical guide on How to use and report (Q)SARs, version 3.1, 2016).

The ChV is defined as the geometric mean of the no observed effect concentration (NOEC) and the lowest observed effect concentration (LOEC) and was predicted to be 23.2 mg/L. The NOEC, which can be derived by dividing the ChV by √2, was determined to be 16.4 mg/L.


 

Conclusions:
The ECOSAR QSAR model (v2.2) predicted a chronic toxicity value (freshwater fish) of 23.2 mg/L. The derived NOEC is considered to be 16.4 mg/L, indicating no long-term toxicity for freshwater fish.
Executive summary:

A Chronic toxicity value (ChV) for freshwater fish was calculated by using the software ECOSAR v2.2 (model "Estimation of Toxicity to Aquatic Organisms Using ECOSAR v2.2: Chemical Class: Amides: Fish Chronic value (ChV)"). The ChV is defined as the geometric mean of the no observed effect concentration (NOEC) and the lowest observed effect concentration (LOEC) and was predicted to be 23.2 mg/L. The NOEC, which can be derived by dividing the ChV by √2, was determined to be 16.4 mg/L.


 

Description of key information

A Chronic toxicity value (ChV) for freshwater fish was calculated by using the software ECOSAR v2.2 (model "Estimation of Toxicity to Aquatic Organisms Using ECOSAR v2.2: Chemical Class: Amides: Fish Chronic value (ChV)"). The ChV, which is defined as the geometric mean of the no observed effect concentration (NOEC) and the lowest observed effect concentration (LOEC), was predicted to be 23.2 mg/L. The NOEC, which can be derived by dividing the ChV by √2, was determined to be 16.4 mg/L.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Dose descriptor:
NOEC
Effect concentration:
16.4 mg/L

Additional information