Registration Dossier
Registration Dossier
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EC number: 210-676-0 | CAS number: 621-29-4
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance is hydrolytically unstable at pH 4, 7 and 9 (half-life less than 12 hours)
Reference
Description of key information
In accordance with column 2 of REACH Annex VII, the study does not need to be conducted as the substance is hydrolytically unstable.
The partition coefficient of the primary amine transformation product has been presented in a separate endpoint summary for use in the CSA.
Key value for chemical safety assessment
Additional information
With reference to Section 5.1.2 endpoint summary, isocyanates (i.e. m-tolyl isocyanate) are rapidly hydrolysed (DT50 <1h) under environmentally relevant conditions. Therefore, it is appropriate to conduct experimental testing (in the aqueous compartment) on the primary amine transformation product, in this instance, m-toluidine.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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