Registration Dossier

Administrative data

Endpoint:
in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
Remarks:
Type of genotoxicity: chromosome aberration
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
4 (not assignable)

Data source

Reference
Reference Type:
publication
Title:
In vivo antimutagenic effect of ascorbic acid against mutagenicity of the common antiamebic drug diiodohydroxyquinoline
Author:
Surendra Ghaskadbi, V.G. Vaidya
Year:
1989
Bibliographic source:
Mutation Research/Genetic Toxicology Volume 222, Issue 3, March 1989, Pages 219-222

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: not available
GLP compliance:
not specified
Type of assay:
micronucleus assay

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
other: oral
Vehicle:
no data
Duration of treatment / exposure:
no data
Frequency of treatment:
no data
Post exposure period:
no data
Doses / concentrations
Remarks:
Doses / Concentrations:
80 mg/kg
Basis:

Control animals:
not specified
Positive control(s):
no data

Results and discussion

Test results
Sex:
not specified
Genotoxicity:
not specified
Toxicity:
not examined
Vehicle controls validity:
not specified
Negative controls validity:
not specified

Applicant's summary and conclusion