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Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
in vitro DNA damage and/or repair study
Remarks:
Type of genotoxicity: DNA damage and/or repair
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
4 (not assignable)

Data source

Reference
Reference Type:
publication
Title:
Genotoxicity of amebicide and anthelmintic drugs in Escherichia coli pol A+/pol A−
Author:
J.J. Espinosa-Aguirre , C. Aroumir, M.T. Meza, E. Cienfuegos, C. Cortinas de Nava
Year:
1987
Bibliographic source:
Mutation Research/Genetic Toxicology Volume 188, Issue 2, June 1987, Pages 111-120

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: not available
GLP compliance:
not specified
Type of assay:
other: no data

Test material

Reference
Name:
Unnamed
Type:
Constituent

Method

Species / strain
Species / strain / cell type:
E. coli, other: pol A+/pol A−
Additional strain / cell type characteristics:
not specified
Metabolic activation:
without
Metabolic activation system:
none
Test concentrations with justification for top dose:
DOSE : 260 nmol/plate
Vehicle / solvent:
no data
Controls
Untreated negative controls:
not specified
Negative solvent / vehicle controls:
not specified
True negative controls:
not specified
Positive controls:
not specified
Positive control substance:
not specified

Results and discussion

Test results
Species / strain:
E. coli, other: pol A+/pol A−
Metabolic activation:
not specified
Genotoxicity:
not specified
Cytotoxicity / choice of top concentrations:
not determined
Vehicle controls validity:
not specified
Untreated negative controls validity:
not specified
Positive controls validity:
not specified
Remarks on result:
other: all strains/cell types tested
Remarks:
Migrated from field 'Test system'.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information):
other: not specified

DNA repair
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 260 nmol/plate