Registration Dossier
Registration Dossier
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EC number: 201-497-9 | CAS number: 83-73-8
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro DNA damage and/or repair study
- Remarks:
- Type of genotoxicity: DNA damage and/or repair
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- publication
- Title:
- Genotoxicity of amebicide and anthelmintic drugs in Escherichia coli pol A+/pol A−
- Author:
- J.J. Espinosa-Aguirre , C. Aroumir, M.T. Meza, E. Cienfuegos, C. Cortinas de Nava
- Year:
- 1 987
- Bibliographic source:
- Mutation Research/Genetic Toxicology Volume 188, Issue 2, June 1987, Pages 111-120
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: not available
- GLP compliance:
- not specified
- Type of assay:
- other: no data
Test material
- Reference substance name:
- Diiodohydroxyquinoline
- EC Number:
- 201-497-9
- EC Name:
- Diiodohydroxyquinoline
- Cas Number:
- 83-73-8
- Molecular formula:
- C9H5I2NO
- IUPAC Name:
- 5,7-diiodoquinolin-8-ol
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- E. coli, other: pol A+/pol A−
- Additional strain / cell type characteristics:
- not specified
- Metabolic activation:
- without
- Metabolic activation system:
- none
- Test concentrations with justification for top dose:
- DOSE : 260 nmol/plate
- Vehicle / solvent:
- no data
Controls
- Untreated negative controls:
- not specified
- Negative solvent / vehicle controls:
- not specified
- True negative controls:
- not specified
- Positive controls:
- not specified
- Positive control substance:
- not specified
Results and discussion
Test results
- Species / strain:
- E. coli, other: pol A+/pol A−
- Metabolic activation:
- not specified
- Genotoxicity:
- not specified
- Cytotoxicity / choice of top concentrations:
- not determined
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
other: not specified
DNA repair
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 260 nmol/plate
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