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Diss Factsheets

Administrative data

Endpoint:
chronic toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
4 (not assignable)

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
RTECS Number : VC5775000
Author:
RTECS handbook
Year:
2012
Bibliographic source:
RTECS (Registry of Toxic Effects of Chemical Substances); LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 1,261,1966
Reference Type:
other: Authoritative data base
Title:
GCID: 477779
Author:
ACToR database
Year:
2011
Bibliographic source:
ACToR (Aggregated Computational Toxicology Resource); Lancet. Vol. 1, Pg. 261, 1966.

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
Data is from RTECS ,SAX handbook and ACToR database.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Diiodohydroxyquinoline
EC Number:
201-497-9
EC Name:
Diiodohydroxyquinoline
Cas Number:
83-73-8
Molecular formula:
C9H5I2NO
IUPAC Name:
5,7-diiodoquinolin-8-ol
Details on test material:
- Name of test material: diiodohydroxyquinoline
- Molecular formula: C9H5I2NO
- Molecular weight: 396.95
- Substance type: organic
- Physical state: solid

Test animals

Species:
other: Human
Strain:
other: not applicable
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
2 years
Frequency of treatment:
intermittent frequency

Results and discussion

Effect levels

Dose descriptor:
other: TDLo
Effect level:
120 000 other: mg/kg
Based on:
test mat.
Sex:
not specified
Basis for effect level:
other: Sense Organs and Special Senses (Eye) - visual field changes

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
Repeated dose oral toxicity value of diiodohydroxyquinoline to Human - child was found to be TDLo(Lowest published toxic dose): 120000 mg/kg, when diiodohydroxyquinoline was administered orally for 2 years.
Executive summary:

Repeated dose oral toxicity value of diiodohydroxyquinoline to Human - child was found to be TDLo(Lowest published toxic dose): 120000 mg/kg, when diiodohydroxyquinoline was administered orally for 2 years.