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Diss Factsheets

Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Referenceopen allclose all

Reference Type:
other: Authoritative data base
Title:
HSDB Number: 3224
Author:
HSDB database
Year:
2011
Bibliographic source:
HSDB (Hazardous Substances Data Bank); US national Library of Medicine reviewed by SRC,Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975. ,p.1073
Reference Type:
other: Authoritative data base
Title:
GCID: 477779
Author:
ACToR database
Year:
2011
Bibliographic source:
ACToR (Aggregated Computational Toxicology Resource),Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 1073

Materials and methods

Objective of study:
absorption
excretion
Test guideline
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
Data is from HSDB and ACToR database.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Diiodohydroxyquinoline
EC Number:
201-497-9
EC Name:
Diiodohydroxyquinoline
Cas Number:
83-73-8
Molecular formula:
C9H5I2NO
IUPAC Name:
5,7-diiodoquinolin-8-ol
Details on test material:
- Name of test material: diiodohydroxyquinoline
- Molecular formula: C9H5I2NO
- Molecular weight: 396.95
- Substance type: organic
- Physical state: solid
Radiolabelling:
not specified

Test animals

Species:
other: no data
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Control animals:
not specified

Results and discussion

Toxicokinetic / pharmacokinetic studies

Details on absorption:
Variable but significant portion of ingested dose was absorbed, diiodohydroxyquin was least well absorbed, only 1/3 as much as iodochlorhydroxyquin
Details on excretion:
Bulk of these drugs was passed in feces.

Metabolite characterisation studies

Metabolites identified:
not specified

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): no bioaccumulation potential based on study results
After an oral administration of diiodohydroxyquinoline it was found that diiodohydroxyquin was least well absorbed, only 1/3 as much as iodochlorhydroxyquin, and bulk of it was passed in feaces.
Executive summary:

After an oral administration of diiodohydroxyquinoline it was found that diiodohydroxyquin was least well absorbed, only 1/3 as much as iodochlorhydroxyquin, and bulk of it was passed in feaces.