Registration Dossier
Registration Dossier
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EC number: 238-925-9 | CAS number: 14858-73-2
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Bis(2-ethylhexyl) carbonate is non-toxic to aquatic invertebrates. LC50 (48 h) and NOEC (48 h) Daphnia magna: > 19.7 µg/L (water solubility limit under test conditions of OECD guideline 202).
Key value for chemical safety assessment
Additional information
In a 48-hour acute toxicity study according to OECD guideline 202(Daphnia sp. Acute Immobilisation Test) (2004), Daphnia magna were exposed under semi-static conditions to Bis(2-ethylhexyl) carbonate at initial mean measured concentrations of 19.7 µg/L (the saturation concentration under test conditions). The water solubility of the test substance according to the sponsor of the study is < 0.03 mg/L. Nominal loading was 30 µg/L. The test item did not cause any toxic effects to the daphnids. This study is classified as reliable without restriction and satisfies the guideline requirements for an acute toxicity study with invertebrates.
LC50 (48 h) and NOEC (48 h) Daphnia magna: > 19.7 µg/L, the saturation concentration under the test conditions. Thus, up to its solubility limit under the test conditions of OECD guideline 202 Bis(2-ethylhexyl) carbonate is not acute toxic to aquatic invertebrates.
This is supported by results obtained from a valid QSAR model: The 48 h LC50 of Bis(2-ethylhexyl) carbonate to daphnia is estimated to be 3.775 mg/L (ECOSAR v1.11).
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