Registration Dossier
Registration Dossier
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EC number: 691-719-4 | CAS number: 1072957-71-1
Endpoint summary
Administrative data
Description of key information
Acute oral MLD = 55 mg/kg (rat); dermal MLD = >2000 mg/kg (rat) and acute inhalation MLC = 0.56 mg/l (rat).
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 55 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 560 mg/m³ air
Additional information
The estimated acute medial lethal dose (MLD) for SYN545192 via the oral route was 55 mg/kg and the median lethal concentration (MLC) following acute inhalation exposure was estimated to be 0.56 mg/l. The acute dermal MLD was shown to be >2000 mg/kg.
Justification for classification or non-classification
Acute oral toxicity: Based on the available information the substance is considered to meet the criteria for classification for "acute oral toxicity", Category 3 – H301: Toxic if swallowed – according to Regulation (EC) 1272/2008, Annex I, Part 3, 3.1.2.
Acute dermal toxicity: Based on the available information the substance does not meet the criteria for classification for "acute dermal toxicity" under Regulation (EC) 1272/2008, Annex I, Part 3, 3.1.2; reason for non-classification: conclusive but not sufficient for classification.
Acute inhalation toxicity: Based on the available information the substance is considered to meet the criteria for classification for "acute inhalation toxicity", Category 3 – H331: Toxic if inhaled – according to Regulation (EC) 1272/2008, Annex I, Part 3, 3.1.2.
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