Registration Dossier
Registration Dossier
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EC number: 691-719-4 | CAS number: 1072957-71-1
Toxicity to birds
Administrative data
Link to relevant study record(s)
Description of key information
LD50: >1014 mg/kg bw (acute oral, northern bobwhite, OECD 223, Hubbard et al, 2009)
20-wk NOEC: 200 mg/kg food, 25.0 mg/kg bw/day (reproduction, mallard, OECD 206, Frey et al, 2011)
Key value for chemical safety assessment
- Long-term EC10, LC10 or NOEC for birds:
- 200 mg/kg food
Additional information
Summary of the data:
LD50: >1014 mg/kg bw (acute oral, northern bobwhite, OECD 223, Hubbard et al, 2009)
LD50: 1450 mg/kg bw (acute oral, northern bobwhite, OPPTS 850.2100, Hubbard et al)
MLD (conservative estimate; regurgitation): 259 mg/kg bw (acute oral, zebra finch, OPPTS 850.2100, Hubbard et al, 2011)
8-d LC50: >5620 mg/kg food, >2761 mg/kg bw/day (dietary, mallard, OECD 205, Hubbard et al, 2010)
8-d LC50: >5620 mg/kg food, >1168 mg/kg bw/day (dietary, northern bobwhite, OECD 205, Hubbard et al, 2010)
20-wk NOEC: 200 mg/kg food, 25.0 mg/kg bw/day (reproduction, mallard, OECD 206, Frey et al, 2011)
20-wk NOEC: 600 mg/kg food, 54.0 mg/kg bw/day (reproduction, northern bobwhite, OECD 206, Frey et al, 2011)
Several studies are available for this endpoint (i.e. acute oral, dietary & reproduction with several species). Due to regurgitation during the test, the study with zebra finch is considered to be of limited relevance and reliability and is not adequate for risk assessment and classification purposes. The other studies are considered to be relevant, reliable, adequate for risk assessment, and adequate for classification purposes. The lowest available LD50 (acute, northern bobwhite) and NOEC (chronic/reproduction, mallard) results are carried forward for risk assessment purposes.
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