Registration Dossier
Registration Dossier
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EC number: 246-376-1 | CAS number: 24634-61-5
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Poorly documented orientating trial, insufficient for assessment of inhalation toxicity.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
- Report date:
- 1971
Materials and methods
- Principles of method if other than guideline:
- Duration of exposure: 2 hours
- GLP compliance:
- no
Test material
- Reference substance name:
- Hexa-2,4-dienoic acid
- EC Number:
- 203-768-7
- EC Name:
- Hexa-2,4-dienoic acid
- Cas Number:
- 110-44-1
- Molecular formula:
- C6H8O2
- IUPAC Name:
- hexa-2,4-dienoic acid
- Details on test material:
- - Name of test material: Sorbic acid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS - type of rabbit: yellow-silver
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose only
- Vehicle:
- other: air
- Details on inhalation exposure:
- Administration: as aerosol (saturated)
Particle size: not stated
Type or preparation of particles: dust generation - Duration of exposure:
- 2 h
- Concentrations:
- no data
- No. of animals per sex per dose:
- Number of animals: 6 (3 per group)
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 d p.a.
- Examinations: behaviour, mortality
Results and discussion
Effect levels
- Key result
- Remarks on result:
- other: No mortality was observed after 7 days. No abnormal behaviour was observed after 7 days.
- Mortality:
- No mortality was observed after 7 days.
- Clinical signs:
- other: No abnormal behaviour was observed after 7 days.
Applicant's summary and conclusion
- Conclusions:
- The extrapolation from sorbic acid to potassium sorbate is considered not to be restricted in any way, since the determinant of potential toxicity is on the "sorbate" anion.
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