Registration Dossier

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Additional information

In vitro, 3-nitrotoluene showed no mutagenic effect in Ames tests with Salmonella typhimurium, with and without metabolic activation. In cultured mammalian cells, 3-nitrotoluene has demonstrated the potential to cause mutagenicity in sister chromatid exchange test in the absence of metabolic activation. In vivo, 3-Nitrotoluene had no genotoxic activity. The substance did not did not induce unscheduled DNA synthesis in rat ex vivo hepatocytes.

Short description of key information:
Ames test conducted with a method equivalent to OECD guideline 471 yielded negative results with and without metabolic activation.
Sister chromatid exchange assay in mammalians cells carried out with a method similar to OECD guideline 479, yielded negative results with and without metabolic activation
Unscheduled DNA Synthesis in male rats yielded negative results

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

Based on the available data there is no reason for classification

Categories Display