Registration Dossier

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable, well documented study report which meets basic scientific principles
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1976
Report date:
1976

Materials and methods

Principles of method if other than guideline:
Dermal exposure (24 hours) to 3-nitrotoluene
GLP compliance:
no
Remarks:
GLP was not mandatory at the time of the study
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
3-nitrotoluene
EC Number:
202-728-6
EC Name:
3-nitrotoluene
Cas Number:
99-08-1
Molecular formula:
C7H7NO2
IUPAC Name:
1-methyl-3-nitrobenzene
Details on test material:
- Name of test material (as cited in study report): m-nitrotoluole
- Physical state: Liquid (clear yellow)
- Analytical purity: no data

Test animals

Species:
rat
Strain:
Wistar

Administration / exposure

Duration of exposure:
24 hours
Doses:
1157 mg/kg bw
No. of animals per sex per dose:
5
Control animals:
other: not applicable

Results and discussion

Effect levels
Dose descriptor:
LD50
Effect level:
> 1 157 mg/kg bw

Applicant's summary and conclusion