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Long-term toxicity to fish

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Reference
Endpoint:
long-term toxicity to fish, other
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment
Principles of method if other than guideline:
according to Canton and Sloof (1982)
GLP compliance:
not specified
Specific details on test material used for the study:
- Name of test material (as cited in study report): 3-Nitrotoluene
- Analytical purity: > 99.5 %
Analytical monitoring:
yes
Details on test solutions:
- Culturing and test medium: NaHCO3 100 mg/l, CaCl2*2H2O 200 mg/l, KHCO3 20 mg/l, MgSO4*7H2O 180 mg/l
Test organisms (species):
Oryzias latipes
Details on test organisms:
- 50 animals (3 - 4 weeks old) each test
- Fish were fed with Tetramine, Tetraphyll
Test type:
semi-static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
28 d
Test temperature:
23 ± 2 °C
Details on test conditions:
- 3-times a week adjustment of the concentration
Duration:
28 d
Dose descriptor:
NOEC
Effect conc.:
2 mg/L
Conc. based on:
test mat.
Basis for effect:
other: mortality + behaviour
Duration:
28 d
Dose descriptor:
LC50
Effect conc.:
9.9 mg/L
Conc. based on:
test mat.
Basis for effect:
mortality
Details on results:
additional parameter: 28d EC50 (mortality + behaviour): 3.0 mg/l
Executive summary:

The toxicity of 3-nitrotoluene to Oryzias latipes was evaluated in a 28 d study performed according to the methodology described by Canton and Sloof (1982). The 28d-NOEC value was determined to be 2 mg/L (Canton et al. 1985).

Description of key information

For transported isolated intermediates according to REACh, Article 18, this endpoint is not a data requirement. However, data is available for this endpoint and is thus reported under the guidance of "all available data".


The toxicity of 3-nitrotoluene to Oryzias latipes was evaluated in a 28 d study performed according to the methodology described by Canton and Sloof (1982). The 28d-NOEC value was determined to be 2 mg/L (Canton et al. 1985).

Key value for chemical safety assessment

Additional information