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Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Remarks:
Type of genotoxicity: gene mutation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
RTECS Number : ZE9450000
Year:
2012
Bibliographic source:
RTECS (Registry of Toxic Effects of Chemical Substances):-MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 77,317,1980
Reference Type:
review article or handbook
Title:
DPIM : XNS000
Author:
Richard J. Lewis, Sr.
Year:
2007
Bibliographic source:
SAX (Sax's Handbook of Dangerous Industrial Materials):-MUREAV  Mutation Research. 77 (1980), 317.

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
RTECS database
GLP compliance:
not specified
Type of assay:
bacterial gene mutation assay

Test material

Reference
Name:
Unnamed
Type:
Constituent

Method

Species / strain
Species / strain / cell type:
bacteria, other: Salmonella typhimurium
Additional strain / cell type characteristics:
not specified
Metabolic activation:
not specified
Metabolic activation system:
none
Test concentrations with justification for top dose:
Dose Data : 5 umol/plate  

Results and discussion

Test results
Species / strain:
bacteria, other: Salmonella typhimurium
Metabolic activation:
not specified
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
not specified
Vehicle controls validity:
not specified
Untreated negative controls validity:
not specified
Positive controls validity:
not specified
Remarks on result:
other: all strains/cell types tested
Remarks:
Migrated from field 'Test system'.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information):
negative
Executive summary:

Mutation in microorganisms : Bacteria - Salmonella typhimurium: 5 umol/plate