Tetraethylammonium heptadecafluorooctanesulphonate

Epidemiological data

Administrative data

Endpoint:

epidemiological data

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: secondary literature

Data source

Reference

Reference Type:

secondary source

Title:

Unnamed

Year:

2001

Report date:

2001

Materials and methods

Study type:

cross sectional study

Endpoint addressed:

not applicable

Principles of method if other than guideline:

cross-sectional data used to determine PFOS levels in the general population

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

PFOS

IUPAC Name:

PFOS

Details on test material:

Identity: PFOS and 6 other fluorochemicals

Method

Details on study design:

Study design: Cross-sectional
Manufacturing/Processing/Use: N/A
Hypothesis tested: To determine the levels of PFOS in the serum of American Red Cross blood banks in
6 regions of the U.S.
Study period: 2000
Setting: N/A
Total population: Serum pooled from 6 ARC blood banks in various geographic regions in the US: Los
Angeles, CA; Minneapolis/St. Paul, MN; Charlotte, NC; Boston, MA; Portland, OR, and Hagerstown, MD.
Subject selection criteria: Unknown
Total # of subjects in study: 652 donors, age 20-69 years
Comparison population: N/A
Participation rate: N/A
Subject description: No information was provided on the individuals from whom the sera samples were
taken.
Health effects studied: PFOS levels in blood
Data collection methods: Blood sera samples were analyzed using high-pressure liquid
chromatography/electrospray tandem mass spectrometry (HPLC/ESMSMS).
Details on data collection: No information was provided as to how the blood was drawn, stored, etc.
Exposure period: Unknown--PFOS serum levels used as surrogate for exposure.
Description/delineation of exposure groups/categories: N/A
Measured or estimated exposure: N/A
Exposure levels: N/A
Statistical methods: Arithmetic means, ranges, geometric means and 95% confidence intervals were
calculated. Central tendency and distribution of the data by age, gender, location
and their respective interaction terms will be done in the final report. A reliability assessment is also being analyzed.
Other methodological information: N/A

Exposure assessment:

not specified

Results and discussion

Results:

The mean serum PFOS level was 43.7 ppb. The range was 4.27 to 1656 ppb. Analyses stratified by age, gender, and geographic location will be forthcoming in the final report.

Confounding factors:

no data

Strengths and weaknesses:

These data are cross-sectional data used to determine PFOS levels in the general population. No other descriptive information about the subjects is available in this preliminary report. The sample size is relatively small.
Blood donors cannot be considered representative of the general population of the US.

Any other information on results incl. tables

no data

Applicant's summary and conclusion

Executive summary:

In a cross sectional study PFOS levels in the serum of American Red Cross blood banks in 6 regions of the U.S. were determined.

The mean serum PFOS level was 43.7 ppb. The range was 4.27 to 1656 ppb.