Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Murine Local Lymph Node Assay: sensitising (EC3 = 1%)

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (sensitising)
Additional information:

In the key study that was performed according to OECD guideline 429 in compliance with GLP the substance showed a skin sensitising effect (BASF SE, 2009). The threshold concentration for sensitisation induction was < 3%. The estimated concentration that leads to the SI of 1.5 for cell count (EC 1.5) and the estimated concentration that leads to the SI of 3.0 for 3H-thymidine incorporation (EC 3) was calculated by semi-logarithmical regression from the results of all concentrations to be about 1%, respectively.

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available
Additional information:

There are no data available concerning respiratory sensitisation.

Justification for classification or non-classification

GHS classification according to Annex I 1272/2008 CLP (EU GHS):

- Skin sensitisation Cat. 1A

- Respiratory sensitisation: data lacking