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Description of key information

Short description of key information on bioaccumulation potential result: 
Evaluation of toxicokinetics of the substance Diethyleneglycol dinitrate - CAS No. 693-21-0 was performed according to the demand given in part 8.8.1 of Annex VIII to the Directive (EC) No. 1907/2006 (REACH) : “Assessment of the toxicokinetic behavior of the substance to the extent that could be derived from the relevant available information”.
The evaluation of toxicokinetics is based on information from three sources:
- Experimental data of toxicological tests
- Literature data obtained from internet
- Data from toxicological databases – free and commercial

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential

Additional information

The substance DEGDN is not absorbed through the skin. After oral or inhalation exposure it is fairly quickly absorbed and systemically distributed through the body (hours). Through the blood circulation it reaches and influences the heart, CNS, liver and kidneys, etc.

In the body the nitrate form is converted to nitrite form which causes the most of symptoms observed after exposition. It seems that the elimination through the kidneys to the urine takes several days after both the lower and higher doses.

Discussion on bioaccumulation potential result:

Probable Routes of Human Exposure

Occupational exposure to Diethylene glycol dinitrate may occur through dermal contact with this compound at workplaces where diethyleneglycol dinitrate is produced or used. Limited exposure to general population to diethyleneglycol dinitrate may occur via inhalation. In sporadic cases the acute oral poisoning is encountered.

 

Toxicokinetics Evaluation Summary

The substance is not absorbed through the skin. After oral or inhalation exposure it is fairly quickly absorbed and systemically distributed through the body (hours). Through the blood circulation it reaches and influences the heart, CNS, liver and kidneys, etc.

In the body the nitrate form is converted to nitrite form which causes the most of symptoms observed after exposition. It seems that the elimination through the kidneys to the urine takes several days after both the lower and higher doses.