Registration Dossier
Registration Dossier
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EC number: 939-514-3 | CAS number: 1471312-26-1
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
No effects up to the limit of water solubility (WS 4-5 mg/L in aqua dest., ASTM E1148).
Key value for chemical safety assessment
Additional information
One experimental study investigating the short-term effects of Propanoic acid, 2-hydroxy-, C12-13-branched-alkyl esters to fish is available (Cattapan, 2008). The study was performed according to OECD 203 (GLP) as a limit test at a nominal concentration of 100 mg/L for 96 h with Brachydanio rerio. Two different approaches were followed in this study regarding test solution preparation. The first approach was performed via direct addition of 100 mg/L to the test medium without further separation or filtration steps. In the second approach a Water Accommodated Fraction (WAF) of nominal 100 mg/L was prepared by stirring and subsequent filtration of undissolved test material. The test material caused mortality in the approach without removal of undissolved test material (LC50 (96 h) < 100 mg/L). After 24 hours all fishes were dead and exhibited a bluish coloration on the ventral side, near the gills. This symptom strongly indicates the possibility of hypoxia (lack of oxygen) due to gill clogging. No mortality was observed in the WAF test (LC50 (96 h) > 100 mg/L). Thus, the mortality in the test performed via direct addition can most likely addressed to be caused by physical effects rather than intrinsic effects by the dissolved fraction of the test substance. Based on the information above, it can be concluded that no toxicological short-term effects on fish are expected up to the limit of water solubility for Propanoic acid, 2-hydroxy-, C12-13-branched-alkyl esters.
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