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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

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Administrative data

Link to relevant study record(s)

Description of key information

Based upon the EC50 value and comparing it with the values for aquatic toxicity as mentioned in the CLP regulation, it is concluded that the chemical 5-nitrovanillin is not expected to have toxic effect on aquatic algae and cyanobacteria upto the concentration level mentioned in the studies.

Key value for chemical safety assessment

EC50 for freshwater algae:
102.49 mg/L
EC10 or NOEC for freshwater algae:
31.747 mg/L

Additional information

The No. of studies were reviewed for Short-term toxicity to fish from reliable sources having Klimisch rating 2 and 4.

The summary of the results are presented below

 

Sr.No

Endpoint

Effect values

Basis for effects

Duration

Species

CAS No.

Sources

1

NOEC

31.7 mg/L

Growth

72 hrs.

Pseudokirchnerella subcapitata

6635-20-7

Predicted data

2

EC50

102 mg/L

-

48 hrs.

green algae

6635-20-7

Predicted data

3

LOEC

>152 mg/L

Mortality

5 days.

Pseudokirchnerella subcapitata

121-33-5

Experimental data

 

 

By applying weight of evidence approach to the target substance 5-nitrovanillin and the read across substance,the endpoint value was found to vary between EC50= 102 mg/L in a 48 hrs.study, and LOEC & NOEC value was found to be 152 & 31 mg/l .on the basis of Growth & mortality effect. Thus considering the CLP Criteria for aquatic classification of the substance, it is concluded that 5-nitrovanillin is non-hazardous to the aquatic environment.