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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Administrative data

Link to relevant study record(s)

Description of key information

In the prediction done using the QSAR model; the 48 hr LC50 to Daphnia magna was predicted to be 131.7071 mg/L. Thus, it can be concluded that the chemical 5-nitrovanillin is not expected to have toxic effect on aquatic invertebrates upto the concentration level mentioned in the study based upon the immobilization effect.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
131.707 mg/L

Additional information

No. of studies were reviewed for Short-term toxicity to fish from reliable sources having Klimisch rating 2 and 4.

The summary of the results are presented below  :

Sr.No

Endpoint

Effect values

Basis for effects

Duration

Species

CAS No.

Sources

1

EC50

131.7 mg/L

Immobilization

48 hrs.

Daphnia magna

6635-20-7

Predicted data

2

EC50

280 mg/L

Intoxcication

48 hrs.

Daphnia magna

6635-20-7

Predicted data

3

EC50

180 mg/L

Mortality

48 hrs.

Daphnia magna

121-33-5

Experimental data

 

 

By applying weight of evidence approach to the target substance 5-nitrovanillin and the read across substance,the endpoint value was found to vary between LC50= 131 to 280mg/L in a 48 hrs.study, on the basis of

Immobilization &

mortality effect. Thus considering the CLP Criteria for aquatic classification of the substance , it is concluded that 5-nitrovanillin is non-hazardous to the aquatic environment