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EC number: 228-567-1 | CAS number: 6297-03-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1997/06/16 - 1997/06/19
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Dioctadecyl ether
- EC Number:
- 228-567-1
- EC Name:
- Dioctadecyl ether
- Cas Number:
- 6297-03-6
- Molecular formula:
- C36H74O
- IUPAC Name:
- 1-(octadecyloxy)octadecane
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: 76410 Saint-Aubin-Les-Elbeuf, France
- Weight at study initiation: 2.1 kg
- diet: Complete pelleted rabbit maintenance diet Energie H326, COFNA (37000 - TOURS, FRANCE)
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
in accordance with the requirements of the 86/609/EEC guideline
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: adjacent eye
- Amount / concentration applied:
- 0.1 g
- Duration of treatment / exposure:
- no details given
- Observation period (in vivo):
- 1h, 24h, 48h, 72h
- Number of animals or in vitro replicates:
- 3 females
- Details on study design:
- The adjacent eye served as a control.
SCORING SYSTEM:
Conjunctivae
Chemosis (A): lids and/or nictitating membranes
No swelling 0
Any swelling above normal(includes nictitating membranes) 1
Obvious swelling with partial eversion of lids 2
Swelling with lids about half closed 3
Swelling with lids more than half closed 4
Discharge (B):
No discharge 0
Any amount different from normal (does not include small amounts observed in inner canthus of normal animals) 1
Discharge with moistening of the lids and hairs just adjacent to the lids 2
Discharge with moistening of the lids and considerable area around the eye 3
Redness (C): refers to palpebral and bulbar conjuntivae, cornea and iris
Blood vessels normal 0
Some blood vessels definitely hyperaemic (injected) 1
Diffuse, crimson colour, individual vessels not easily discernible 2
Diffuse beefy red 3
Iris (D)
Normal 0
Markedly deepened rugae, congestion, swelling, moderate circumcorneal hyperaemia, 1
or injection, any of these or combination of any thereof, iris still reacting to light (sluggish reaction is positive)
No reaction to light, haemorrhage, gross destruction (any or all of these) 2
Cornea
Opacity (E): degree of density (area most dense are taken for reading)
No ulceration or opacity 0
Scattered or diffuse areas of opacity (other than slight
dulling of normal lustre), details of iris clearly visible 1
Easily discernible translucent area, details of iris slightly obscured 2
Nacreous area, no details of iris visible, size of pupil barely discernible 3
Opaque cornea, iris not discernible through the opacity 4
Area of cornea involved (F)
One-quarter (or less) but not zero 1
Greater than one-quarter-less than one-half. 2
Greater than one-half-less than three quarters 3
Greater than three-quarters-up to whole area 4
TOOL USED TO ASSESS SCORE:
Ocular reactions are performed with a U.V. and white magnification light. After recording the observations at 24 hours, the eyes of all rabbits are examined with the aid of fluorescein.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Remarks:
- mean
- Time point:
- other: 1h, 24h, 48h, 72h
- Score:
- 0.3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48h
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Remarks:
- mean
- Time point:
- other: 1h, 24h, 48h, 72h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Remarks:
- mean
- Time point:
- other: 1h, 24h, 48h, 72h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- conjunctivae score
- Remarks:
- Discharge
- Basis:
- animal #1
- Remarks:
- mean
- Time point:
- other: 1h, 24h, 48h, 72h
- Score:
- 0
- Max. score:
- 3
- Irritation parameter:
- conjunctivae score
- Remarks:
- Discharge
- Basis:
- animal #2
- Remarks:
- mean
- Time point:
- other: 1h, 24h, 48h, 72h
- Score:
- 0
- Max. score:
- 3
- Irritation parameter:
- conjunctivae score
- Remarks:
- Discharge
- Basis:
- animal #3
- Remarks:
- mean
- Time point:
- other: 1h, 24h, 48h, 72h
- Score:
- 0
- Max. score:
- 3
- Irritation parameter:
- conjunctivae score
- Remarks:
- Redness
- Basis:
- animal #1
- Remarks:
- mean
- Time point:
- other: 1h, 24h, 48h, 72h
- Score:
- 0.3
- Max. score:
- 3
- Reversibility:
- fully reversible within: 48h
- Irritation parameter:
- conjunctivae score
- Remarks:
- Redness
- Basis:
- animal #2
- Remarks:
- mean
- Time point:
- other: 1h, 24h, 48h, 72h
- Score:
- 0.3
- Max. score:
- 3
- Reversibility:
- fully reversible within: 48h
- Irritation parameter:
- conjunctivae score
- Remarks:
- Redness
- Basis:
- animal #3
- Remarks:
- mean
- Time point:
- other: 1h, 24h, 48h, 72h
- Score:
- 0.3
- Max. score:
- 3
- Reversibility:
- fully reversible within: 48h
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Remarks:
- mean
- Time point:
- other: 1h, 24h, 48h, 72h
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- iris score
- Basis:
- animal #2
- Remarks:
- mean
- Time point:
- other: 1h, 24h, 48h, 72h
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- iris score
- Basis:
- animal #3
- Remarks:
- mean
- Time point:
- other: 1h, 24h, 48h, 72h
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- cornea opacity score
- Remarks:
- Opacity
- Basis:
- animal #1
- Remarks:
- mean
- Time point:
- other: 1h, 24h, 48h, 72h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- cornea opacity score
- Remarks:
- Opacity
- Basis:
- animal #2
- Remarks:
- mean
- Time point:
- other: 1h, 24h, 48h, 72h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- cornea opacity score
- Remarks:
- Opacity
- Basis:
- animal #3
- Remarks:
- mean
- Time point:
- other: 1h, 24h, 48h, 72h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- cornea opacity score
- Remarks:
- Opacity area
- Basis:
- animal #1
- Remarks:
- mean
- Time point:
- other: 1h, 24h, 48h, 72h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- cornea opacity score
- Remarks:
- Opacity area
- Basis:
- animal #2
- Remarks:
- mean
- Time point:
- other: 1h, 24h, 48h, 72h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- cornea opacity score
- Remarks:
- Opacity area
- Basis:
- animal #3
- Remarks:
- mean
- Time point:
- other: 1h, 24h, 48h, 72h
- Score:
- 0
- Max. score:
- 4
Any other information on results incl. tables
After 1h an outbreak of diffuse purple enanthemae with lacrimations; slight chemosis in one of them; after 24h a slight redness remains visible in the three animals with the persistence of the slight chemosis in one animal.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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