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Key value for chemical safety assessment

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Data on long-term toxicity to aquatic invertebrates are available in the WHO Concise International Chemical Assessment Document 20 (CICAD) on Mononitrophenols (2000), the BUA report 75 for 2- and 4-nitrophenol (1992; update supplementary report 2003) and the ECB IUCLID (2000) for 2-nitrophenol.

2-Nitrophenol was tested in semi-static 21 d guideline studies according to OECD 202 with Daphnia magna. Two comparable studies are available. However, only one study can be regarded as reliable. The NOEC after 21 d was determined to be 5 mg/L.