4,4'-Isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane, reaction products with biphenyl-4-ol

Long-term toxicity to aquatic invertebrates

Description of key information

A study was conducted to determine the effects of the test substance on the reproductive capacity of Daphnia magna according to OECD Guideline 211 and OECD Guidance document 23. The reproduction test was done as a limit test based on the results of a preceding range-finding study. The reproduction test was performed in a semi-static system. The study duration was 21 d and the test solutions were renewed every 48 h. 3 out 20 parental daphnids in the control and 1 out of 20 daphnid died in the test group. On average, 92 offspring were produced per surviving daphnid in the control treatment whereas 101 offspring were counted on average in the treatment group. There was no delay in first reproduction in the test group in comparison to the control. There were a few insignificant recordings of immobile young and appearance of unhatched (aborted) eggs in the test group during the 21 -d test period. The mean body length of the parents exposed to the control and the test substance group were comparable. The concentrations measured in the freshly prepared test solutions ranged between 0.035 and 0.218 mg/L (average measured concentration of 0.068 mg/L) and were expected to be above the water solubility limit of the test substance (<0.025 mg/L). The study met the acceptability criteria prescribed by the study plan and was considered valid.Under the study conditions, the 21-d NOEC and EC10 of the test substance for reproduction in Daphnia magna was determined to be 0.068 mg/L (average measured concentration) (Migchielsen, 2017).

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Effect concentration:

0.068 mg/L