Registration Dossier
Registration Dossier
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EC number: 220-822-5 | CAS number: 2909-38-8
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No OECD Guideline or GLP defined.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
- Principles of method if other than guideline:
- Acute dermal toxicity study in male rats.
- GLP compliance:
- not specified
- Test type:
- other: Acute dermal toxicity study in male rats
- Limit test:
- no
Test material
- Reference substance name:
- 3-chlorophenyl isocyanate
- EC Number:
- 220-822-5
- EC Name:
- 3-chlorophenyl isocyanate
- Cas Number:
- 2909-38-8
- Molecular formula:
- C7H4ClNO
- IUPAC Name:
- 1-chloro-3-isocyanatobenzene
- Details on test material:
- Liquid substance, no data on purity or further data on test material given.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: BOR: WISW (SPF CpB)
- Sex:
- male
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- no data
- Doses:
- 1.0, 2.5 ml/kg bw.
- No. of animals per sex per dose:
- 10
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 2.5 mL/kg bw
- Remarks on result:
- other: Following signs of toxicity were observed: skin-necrosis, loss of body weight, pain-sensation and diminuation of general condition.
Any other information on results incl. tables
Results:Results
| Toxicological results | ||||||||||||||
| Dose (ml/kg) | sex | died animals | Symptom. animals | animals used | Timepoint of death | starting point of symptoms | Diminuated general condition | Skin necrosis | Nausea | Heightened diuresis | face-down/lateral position | Sedation | Loss of bw. | Pain-sensation(screaming) |
| 1.0 | male | 0 | 0 | 10 | / | / | / | / | / | / | / | / | / | / |
| 2.5 | male | 0 | 10 | 10 | / | 5 min | + | + | / | / | / | / | + | + |
Applicant's summary and conclusion
- Executive summary:
In an acute dermal toxicity test in male rats the test substance was applied once to the skin of the animals. The doses tested were: 1.0 and 2.5 ml/kg bw. The observation period was 14 days. Following signs of toxicity were observed: skin-necrosis, loss of body weight, pain-sensation and diminuation of general condition.
The LD50 was found to be >2.5 ml/kg bw.
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