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EC number: 407-230-4 | CAS number: 126637-70-5 BLUE GS 1259 R5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1990-10-19 to 1991-03-13
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline-conform study under GLP without deviations.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Dilithium disodium (5,5'-diamino-(μ-4,4'-dihydroxy-1:2-κ-2,O4,O4',-3,3'-[3,3'-dihydroxy-1:2-κ-2-O3,O3'-biphenyl-4,4'-ylenebisazo-1:2-(N3,N4-η:N3',N4'-η)]-dinaphthalene-2,7-disulfonato(8)))dicuprate(2-)
- EC Number:
- 407-230-4
- EC Name:
- Dilithium disodium (5,5'-diamino-(μ-4,4'-dihydroxy-1:2-κ-2,O4,O4',-3,3'-[3,3'-dihydroxy-1:2-κ-2-O3,O3'-biphenyl-4,4'-ylenebisazo-1:2-(N3,N4-η:N3',N4'-η)]-dinaphthalene-2,7-disulfonato(8)))dicuprate(2-)
- Cas Number:
- 126637-70-5
- Molecular formula:
- Hill formula: C32 H16 Cu2 Li2 N6 Na2 O16 S4 CAS formula: C32 H16 Cu2 N6 O16 S4. 2Li 2Na
- IUPAC Name:
- dicopper(2+) dilithium(1+) disodium 4,4'-bis[2-(8-amino-1-oxido-3,6-disulfonatonaphthalen-2-yl)diazen-1-yl]-[1,1'-biphenyl]-3,3'-bis(olate)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Remarks:
- Distilled water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 56 - 180 mg/l
- Amount of vehicle (if gavage): 10 ml/kg bw
- Justification for choice of vehicle: no justification given
- Lot/batch no. (if required): not applicable
- Purity: chemical analysis of water given in the original study report
MAXIMUM DOSE VOLUME APPLIED: 1800 mg/kg body weight. (per 10 ml vehicle / kg bw)
DOSAGE PREPARATION (if unusual): not applicable
CLASS METHOD (if applicable)
not applicable - Doses:
- 560, 1000, and 1800 mg/ kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Days 1 (pre-administration), 8 and 15 and at death (if found dead after day 1).
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight - Statistics:
- The LD50 values and the associated 95% confidence interval, the slope of the dose mortal i t y curve were calculated using the Maximum lilkelihood method (Finney, D.J. Probit Analyses, 3rd Edn., Cambridge University Press, 1971).
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 406 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 1 012 - 3 186
- Remarks on result:
- other: Slope of the mortality curve: 3.7
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 571 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 1 130 - 3 909
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 228 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Estimated value, calculations invalid according to Finney.
- Clinical signs:
- other: Signs of systemic toxicity observed during the study period in each dose group were as follows: 1800 mg/kg body weight: lethargy, piloerection, hunched posture, absence of reaction to external stimuli, dark appearance of the eyes - ears - tail 1000 mg/kg
- Gross pathology:
- Macroscopic post mortem examination of the animals that died during the study revealed the following abnormalities in each group:
1800 mg/kg body weight: bluelgreen organs, blue stomach contents
1000 mg/kg body weight: bluelgreen organs, blue stomach contents
560 mg/kg body weight: haemorrhages in the glandular stomach
Macroscopic post mortem examination of the surviving animals at termination did not reveal any abnormalities that were not commonly noted among rats of this age and strain. One male of the 1800 mg/kg group and 1 male of the 1000 mg/kg group were partially cannibalised. - Other findings:
- - Organ weights: not recorded
- Histopathology: not conducted
- Potential target organs: not specified
- Other observations:
Any other information on results incl. tables
Tab. 1: The following mortality rates were observed:
Dose level mg/kg bw | Males | Females | Sexes combined | |
1800 | 3 / 5 | 4 / 5 | 7 / 10 | |
1000 | 1 / 5 | 1 / 5 | 2 / 10 | |
560 | 0 / 5 | 1 / 5 | 1 / 10 |
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- The oral LD50 value of the substancein rats was 1406 mg/kg body weight for the sexes combined and 1571 mg/kg body weight for males alone. The estimated value for females alone was 1228 mg/kg body weight. According to the new CLP regulation (EU version of the UN GHS), the substance should be classified as acute oral. tox. category 4.
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