Registration Dossier
Registration Dossier
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EC number: 609-664-1 | CAS number: 393-85-1
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: EC-guideline 92/69/EC,C.7
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 5-Fluoro-2-nitrobenzoic acid methyl ester
- EC Number:
- 609-664-1
- Cas Number:
- 393-85-1
- Molecular formula:
- C8H6FNO4
- IUPAC Name:
- 5-Fluoro-2-nitrobenzoic acid methyl ester
- Details on test material:
- Purity: 96.6 %
Constituent 1
Results and discussion
- Preliminary study:
- Preliminary test was performed at 50 °C +/- 0.5°C at three pH: 4.0, 7.0 and 9.0.
Dissipation DT50 of parent compoundopen allclose all
- pH:
- 4
- Temp.:
- 50 °C
- DT50:
- 1 yr
- pH:
- 7
- Temp.:
- 50 °C
- DT50:
- 5 - 6 d
- pH:
- 9
- Temp.:
- 50 °C
- DT50:
- < 1 d
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- 159 d
- Details on results:
- Summing up, it can be said that the hydrolysis of 5-Fluoro-2-nitrobenzoic acid methyl ester was base catalysed.
Applicant's summary and conclusion
- Conclusions:
- At pH4 the test substance was stable, because less than 10% was hydrolized after 5 days at 50 °C. This corresponds to a half life time of more than one year at normal environmental conditions.
At pH9 the test substance was instable because it has hydrolized more than 50 % after 2.4 hours.
The half life at pH 7 and 25 °C the half life was 3665 hours.
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