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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Justification for type of information:
Data is from Danish QSAR

Data source

Reference
Reference Type:
other: Predicted database
Title:
Danish QSAR study for the CAS 95-78-3
Author:
Danish (Q)SAR Database
Year:
2019
Bibliographic source:
Database developed by National Food Institute, Technical University of Denmark, with support from the Danish Environmental Protection Agency, the Nordic Council of Ministers and the European Chemicals Agency.

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: Estimated data
Principles of method if other than guideline:
The data predicted using the Danish (Q)SAR Database
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
- Name of test material: 2, 5-xylidine
- Molecular formula: C8H11N
- Molecular weight: 121.18
- Substance type: Organic
- Physical state: Liquid
- Analytical purity: >=97%

Test animals

Species:
rabbit
Strain:
not specified
Details on test animals and environmental conditions:
not specified

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
not specified
Duration of treatment / exposure:
not specified
Observation period:
not specified
Number of animals:
not specified
Details on study design:
not specified

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: not specified
Reversibility:
not specified
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
not specified
Other effects:
not specified

Any other information on results incl. tables

Table showing skin irritation estimation by four different models i.e, Battery,SciQSAR ,CASE Ultra

and Leadscope.The average skin irritation results was given by the first model i.e, Battery model.

DK

Battery

Ultra Leadscope

Leadscope

SciQSAR

Skin irritation in

rabbit

NEG_IN

NEG_IN

NEG_IN

INC_OUT

Domain

IN

IN

IN

OUT

 

Where,

IN = inside applicability domain

OUT = outside applicability domain

Applicant's summary and conclusion

Interpretation of results:
other: not irritating
Conclusions:
No severe skin irritation effects of the test chemical were estimated in rabbit skin by three different models i.e, Battery, Leadscope and CASE Ultra used within Danish QSAR database.
Executive summary:

Skin irritation effects were estimated by three different models i.e, Battery, Leadscope and CASE Ultra used within Danish QSAR database for the test chemical. Based on estimation, No severe skin irritation effects were known when the test chemical was exposed to rabbit skin.