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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from publication

Data source

Referenceopen allclose all

Reference Type:
other: authoritative database
Title:
Acute oral toxicity of test chemical in rats
Author:
U.S. National Library of Medicine
Year:
2018
Bibliographic source:
Chemidplus Database,U.S. National Library of Medicine,2018
Reference Type:
review article or handbook
Title:
Acute oral toxiciy study of test chemical in rats
Author:
K.C. Back et. al.
Year:
1972
Bibliographic source:
National Technical Information Service.
Reference Type:
review article or handbook
Title:
Acute oral toxicity of test chemical in rats
Author:
U.S. Richard J. Lewis
Year:
2012
Bibliographic source:
Sax's Dangerous Properties of Industrial Materials, 12th Edition, 5 Volume Set,2012

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: As mentioned below
Principles of method if other than guideline:
Acute oral toxicity study of test chemical on rats
GLP compliance:
not specified
Test type:
standard acute method

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid
Details on test material:
- Name of test material: 2, 5-xylidine
- Molecular formula: C8H11N
- Molecular weight: 121.18
- Substance type: Organic
- Physical state: Liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
Not specified
Doses:
937mg/kg bw - 2135 mg/kg bw
No. of animals per sex per dose:
Not specified
Control animals:
not specified
Details on study design:
Not specified
Statistics:
Not specified

Results and discussion

Preliminary study:
Not specified
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1 297 mg/kg bw
Based on:
test mat.
95% CL:
>= 937 - <= 2 135
Remarks on result:
other: 50% mortality observed
Mortality:
50% mortality observed
Clinical signs:
Not specified
Body weight:
Not specified
Gross pathology:
Not specified
Other findings:
Not specified

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
Acute oral toxicity value of test chemical to rats was determined to be LD50:1297 mg/kg with 95% confidence limits (937-2135).
Executive summary:

In acute oral toxicity study, rats were treated with test chemical at a concentration of 937 - 2135 mg/kg bw orally. 50% mortality was observed at 1297 mg/kg bw in treated rat. Therefore, LD50 was considered to be 1297 mg/kg bw with 95% confidence limits (937 -2135) when rats were treated with test chemical orally and the test chemical can be classified as acute oral toxic category 4 as per CLP regulation.