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Ecotoxicological information

Short-term toxicity to fish

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Reference
Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Authoritative database
Justification for type of information:
Data is from authoritative database
Qualifier:
according to
Guideline:
OECD Guideline 203 (Fish, Acute Toxicity Test)
Principles of method if other than guideline:
To determine short-term toxicity according to OECD Guideline 203 (Fish, Acute Toxicity Test) of the test chemical on fish in a static system
GLP compliance:
no
Analytical monitoring:
no
Vehicle:
no
Test type:
static
Water media type:
freshwater
Total exposure duration:
96 h
Reference substance (positive control):
no
Key result
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
> 110 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Validity criteria fulfilled:
no
Conclusions:
short-term toxicity of the test chemical was determined, according to OECD Guideline 203 (Fish, Acute Toxicity Test) in a static system, at >110 mg/l.
Executive summary:

Experiment was performed to determine the short-term toxicity of the test material, according toOECD Guideline 203 (Fish, Acute Toxicity Test) in a static system for the duration of 96h. After the exposure of the test chemical to the fish for 96h, the LC50 was determined to be >110 mg/l. Since the value is greater than 110mg/l, the test chemical is considered to b not classified.

Description of key information

Experiment was performed to determine the short-term toxicity of the test material, according to OECD Guideline 203 (Fish, Acute Toxicity Test) in a static system for the duration of 96h. After the exposure of the test chemical to the fish for 96 hours, the LC50 was determined at >110 mg/l. Since the value is greater than 110mg/l, the test chemical is considered to be not classified.

Key value for chemical safety assessment

LC50 for freshwater fish:
110 mg/L

Additional information

Based on the experimental data, toxicity of test chemical was determined on the basis of mortality of fishes. The studies are summarized as below:

First experiment was performed to determine the short-term toxicity of the test material, according to OECD Guideline 203 (Fish, Acute Toxicity Test) in a static system for the duration of 96h. After the exposure of the test chemical to the fish for 96 hours, the LC50 was determined at >110 mg/l. Since the value is greater than 110mg/l, the test chemical is considered to b not classified.

Second experiment was performed from secondary source to support the first experimental study for determining the toxicity of test chemical.

Aim of second experimental study was to determine the effect of test chemical to Oryzias latipes for 48h. After 48h of exposure, the LC50 value was determined to be 239 mg/l. Based on the above value, the chemical is considered to be not classified.

Further, the third experimental study was conducted to determine the toxicity of the test chemical on the mortality of fishes.

Aim of the third study was to determine the effect of test chemical on the mortality of fishes. The LC50 value was determined to be 58 mg/l. Based on the above value and according to the classification, the chemical is classified under aquatic chronic 3.

Hence, based on the maximum experimental values, it can be concluded that the chemical is not classified.

Based on the experimental data, toxicity of test chemical was determined on the basis of immobility rate of aquatic invertebrates. The studies are summarized as below:

First study was conducted to determine the effect of test chemical on the immobility rate of daphnia. A 48 hours study was conducted according to OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test) to determine the toxicity of the test material on daphnia in a static system. After 48 hours of exposure, EC50 was determined at 18 mg/l. Hence on the basis of above data, test chemical was classified under aquatic chronic 3.

Second study was performed from secondary source to support the first experimental study for determining the toxicity of test chemical.

Test was performed to determine the toxicity of the test chemical on aquatic invertebrates (crustaceans). The value of LC50 was determined to be 62 mg/l, based on which the test chemical was considered to be toxic and can be classified under aquatic chronic 3.

Thus, based on the above experimental data, it can be concluded that the chemical is toxic and can be considered to be classified under aquatic chronic 3.