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Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Reference
Endpoint:
bioaccumulation in aquatic species: fish
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from authoritative database and seconday source
Qualifier:
according to
Guideline:
other: Bioaccumulation test of a chemical substance in fish or shellfish provided in the Notice on the Test Method Concerning New Chemical Substances
Principles of method if other than guideline:
To determine bioaccumulation of test chemical
GLP compliance:
not specified
Test organisms (species):
Cyprinus carpio
Details on test organisms:
- Common name: common carp
- Length at study initiation: 8 cm
Route of exposure:
aqueous
Test type:
static
Water / sediment media type:
natural water: freshwater
Total exposure / uptake duration:
6 wk
Nominal and measured concentrations:
1st Concentration area: 1 mg/L,
2nd Concentration area: 0.1 mg/L
Lipid content:
3.7 %
Time point:
start of exposure
Key result
Conc. / dose:
1 mg/L
Type:
BCF
Value:
1.5 L/kg
Basis:
whole body w.w.
Time of plateau:
6 wk
Remarks on result:
other: No other data available
Conc. / dose:
0.1 mg/L
Type:
BCF
Value:
3.8 <= L/kg
Basis:
whole body w.w.
Time of plateau:
6 wk
Remarks on result:
other: No other data available

Bioaccumulation test results

 

2W

3W

4W

6W

1st Concentration

area

Test substance

concentration (mg/L)

0.964

0.955

0.960

0.970

Bioconcentration

factor (L/kg)

2.6

2.0

2.6

1.5

3.2

1.7

2.4

1.8

2nd Concentration

area

Test substance

concentration (mg/L)

0.0956 

0.0950

0.0986

0.101

Bioconcentration

factor (L/kg)

<= 3.8

<= 3.8

<= 3.8

<= 3.8

<= 3.8

<= 3.8

<= 3.8

<= 3.8

Validity criteria fulfilled:
not specified
Conclusions:
The Bioaccumulation factor (BCF) for the substance was determined to be at 1.5 L/kg for 1 mg/L and <= 3.8 L/kg for 0.1 mg/L
Executive summary:

Study was conducted to determine the bioaccumulation of test chemical in Cyprinus carpio. After the exposure of test chemical with Cyprinus carpio, it was observed that the chemical is non-bioaccumulative as BCF was deteremined to be 1.5 L/kg for 1 mg/L

Description of key information

The Bioaccumulation factor (BCF) for the substance was determined to be at 1.5 L/kg for 1 mg/L and<= 3.8 L/kg for 0.1 mg/L

 

Key value for chemical safety assessment

Additional information

Following study includes experimental study for the target chemical to observe the bioconcentration of test chemical.

Study (J-check) was conducted to determine the bioaccumulation of test chemical in Cyprinus carpio. After the exposure of test chemical with Cyprinus carpio, it was observed that the chemical is non-bioaccumulative as BCF was deteremined to be at 1.5 L/kg for 1 mg/L and <= 3.8 L/kg for 0.1 mg/L