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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Effects on fertility

Effect on fertility: via oral route
Dose descriptor:
NOAEL
1 000 mg/kg bw/day
Additional information

The key study for repeated dose toxicity is the only reliable study for this endpoint, based on read-across from the related substance triethoxyisobutylsilane (CAS 17980-47-1). The registered substance, trichloroisobutylsilane, and the surrogate substance both hydrolyse in contact with water to produce the common hydrolysis product isobutylsilanetriol, with the other hydrolysis products being hydrogen chloride and ethanol respectively. Although at pH 7, the triethoxy analogue hydrolyses more slowly than the trichloro (half-life 22 hours compared to <1 minute), under acidic conditions such as in the stomach following oral ingestion, the triethoxy substance is expected to hydrolyse rapidly, based on experience with other ethoxy silanes.

Hydrogen chloride, generated by hydrolysis of trichloroisobutylsilane can be expected to cause local irritant or corrosive effects at sufficiently high concentrations. These effects are not addressed by the read-across data.


Short description of key information:
Only one study examining toxicity to reproduction was included in this dataset. This study was a one-generation oral study (OECD 415) in which the read across substance, triethoxyisobutylsilane, was given by gavage at up to 1000 mg/kg bw/day in arachis oil to male and female rats for 10 wk prior to mating and throughout gestation and lactation. The study found no evidence of adverse reproductive effects in the parents or offspring.

Effects on developmental toxicity

Description of key information
The key developmental toxicity study was an oral study in rats conducted according to OECD 414, with gavage administration of up to 1000 mg/kg bw/day of the read across substance, triethoxyisobutylsilane, in arachis oil on gestation days 6-15 and examination at gestation day 20. The study reported slight maternal toxicity but no evidence developmental effects at 1000 mg/kg bw/day. No maternal toxicity was seen at the lower dose of 250 mg/kg bw/day.
Effect on developmental toxicity: via oral route
Dose descriptor:
NOAEL
1 000 mg/kg bw/day
Additional information

The key study for repeated dose toxicity is the only reliable study for this endpoint, based on read-across from the related substance triethoxyisobutylsilane (CAS 17980 -47 -1). The registered substance, trichloroisobutylsilane, and the surrogate substance both hydrolyse in contact with water to produce the common hydrolysis product isobutylsilanetriol, with the other hydrolysis products being hydrogen chloride and ethanol respectively. Although at pH 7, the triethoxy analogue hydrolyses more slowly than the trichloro (half-life 22 hours compared to <1 minute), under acidic conditions such as in the stomach following oral ingestion, the triethoxy substance is expected to hydrolyse rapidly, based on experience with other ethoxy silanes.

Hydrogen chloride, generated by hydrolysis of trichloroisobutylsilane can be expected to cause local irritant or corrosive effects at sufficiently high concentrations. These effects are not addressed by the read-across data.

Justification for classification or non-classification

The available data do not support classification for reproductive or developmental toxicity under Regulation (EC) No 1272/2008 or Directive 67/548/EEC.

 

Additional information