Trifluoroacetic anhydride

Direct observations: clinical cases, poisoning incidents and other

Administrative data

Endpoint:

direct observations: clinical cases, poisoning incidents and other

Type of information:

other: case report

Adequacy of study:

supporting study

Study period:

2002

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: only few details are given.

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

reference to same study

Cross-reference 2

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

publication

Title:

Unnamed

Year:

2002

Materials and methods

Study type:

poisoning incident

Endpoint addressed:

skin irritation / corrosion

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

poisoning incident in a 21 year old woman studying chemistry at the university.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Trifluoroacetic anhydride

EC Number:

206-982-9

EC Name:

Trifluoroacetic anhydride

Cas Number:

407-25-0

Molecular formula:

C4F6O3

IUPAC Name:

trifluoroacetic anhydride

Details on test material:

- Name of test material (as cited in study report): Trifluoroacetic anhydride
- Analytical purity: 100%

Method

Type of population:

other: student

Subjects:

- Number of subjects exposed: one
- Sex: female
- Age: 21
- Race: no data
- Demographic information: no data
- Known diseases: no data

Ethical approval:

not applicable

Route of exposure:

dermal

Reason of exposure:

accidental

Exposure assessment:

not specified

Details on exposure:

While she was pipetting TFAH during an experiment, the pipette holder suddenly separated from the pipette and Trifluoroacetic anhydride lliquid spilled over her left thigh and right upper arm.

Examinations:

- Urine analysis: no
- Haematology: no
- Lung function parameters: no
- Other: examination of the skin

Medical treatment:

Her teacher rapidly washed her thigh and arm with large amounts of water for 30 min. Afer this, he soaked her thigh and arm with diluted bicarbonate for a while, washed then with water again and brought her to the hospital.

Results and discussion

Clinical signs:

She developped an oedematous erythema on her left thigh and right upper arm associated with some discoloration. There was no vesiculation, bulla formation or erosion. She complained for severe pain.

Results of examinations:

- Urine analysis: no data
- Haematology: no data
- Lung function parameters: no data
- Other: severe burns of the skin

Effectivity of medical treatment:

After treatment with betamethasone valerate ointment for several hours, the pain gradually subsided. Application of 8.5% calcium gluconate to the erythematous region increased the pain and azulene ointment was substituted for the calcium gluconate. A week later, the sites became ulcerated. We applied silver sulfadiazine ointment and the ulcers healed gradually.

Outcome of incidence:

It took 50 days for complete epithelization of all lesions. There remain hyperpigmentation and hypertrophic scarring, and local compression with a pressure sponge is still being applied.

Any other information on results incl. tables

None.

Applicant's summary and conclusion

Conclusions:

An accidental skin contact with trifluoroacetic anhydride induced severe skin burns.

Executive summary:

A 21 year-old woman, studying chemistry at university, was pipetting 100% trifluoroacetic anhydride (TFAH), when the pipette holder suddenly separated from the pipette. TFAH liquid spilled over her left tigh and right upper arm. Her teacher washed her thigh and arm with water and bicarbonate. When she arrived at the hospital, an oedematous erythema was observable on her thigh and arm associated with discoloration but without vesiculation, bulla formation or erosion. She complained of severe pain. Several local treatments were applied on the burns. One week after the accident, the sites became ulcerated. 50 days after the accident, complete epithelization of all lesions was observed, but there remained hyperpigmentation and hypertrophic scarring.