Undecanal

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2009-11-11 to 2010-02-25

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Version / remarks:

adopted on 27 July 1995

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Version / remarks:

Directive 92/69/EEC, Official Journal L 383 A 1992

Deviations:

no

GLP compliance:

yes

Type of method:

flask method

Key result

Water solubility:

12 mg/L

Conc. based on:

test mat.

Loading of aqueous phase:

0.1 g/L

Incubation duration:

>= 24 - <= 72 h

Temp.:

30 °C

pH:

ca. 6.7

Remarks on result:

other: Determination of concentration after equlibraton for 24 h at 20°C +/- 0.5 °C and filtration (nylon; 0.20 µm)

Details on results:

See section "Any other information on results incl. tables"!

Preliminary test

The test item was dissolved in the pre-sample with a concentration of approx. 10E-02 g/l (see table below). Thus the flask method was performed.

	Amount of test item [µL]	Amount of test item [mg]^I)	Volume of water [mL]	Visual observation	Concentration of test item [mg/L]
Pre-sample 1	12	10	1000	Dissolved	10
Pre-sample 2	24	20	1000	Not dissolved	20

1) calculated with the density (0.826 -0.837 g/cm^3)

Main test, results:

Sample no	Amount of test item [mg]	Added volume of water [mL]	Shaking time at 30°C [h]	Analysed carbon concentration [mg C/L]	Concentration of the test item [mg/L]^1)	pH value^2)
1	10.22	100	24	9	12	6.73
2	10.06	100	24	8	10	6.79
3	10.20	100	48	8	10	6.71
4	10.82	100	48	10	13	6.61
5	10.00	100	72	9	12	6.67
6	10.12	100	72	9	12	6.65

1) calculated from the carbon concentration of the sample solutions and the carbon content of the pure test item (77.1 %)

2) The purified water used for the tests had a pH value of 7.60.

Descriptive statistics for samples one to 6:

- arithmetic mean value: 12 mg/L

- standard deviation (SD): 1 mg/L

- relative SD: 10.6%

Water solubility as a function of time:

- n=2 after 24 h at 30 °C: 11 mg/L;

- n=2 after 48 h at 30 °C: 12 mg/L

- n=2 after 72 h at 30 °C: 12 mg/L

The relative standard deviation (repeatability) of the concentrations in all six samples was smaller than 15 % and the three duplicate sets of samples showed no tendency of increasing concentration

values. Thus the test was satisfactory.

Conclusions:

Solubility in water (OECD 105, flask method): 12 mg/L at 20°C

Executive summary:

The water solubility of the test item was determined compliant with GLP according to OECD guideline no. 105 and EU test method A.6 with the flask method. Incubation was performed over 24 h, 48 h and 72 h at 30 °C (n= 2 for each time period) followed by equilibration at 20 °C for 24 hours. Even after centrifugation samples were slightly turbid. Therefore, filtration over nylon (0.20 µm) filter was performed before determination of concentration by carbon analysis (TOC). The relative standard deviation (repeatability) of the concentrations over all six samples was smaller than 15 % and the three duplicate sets of samples (incubation time at 30 °C: 24 h; 48 h; and 72 h) showed no tendency of increasing concentration values over time. Thus the test was satisfactory.

Result:

Solubility in water (OECD 105, flask method): 12 mg/L at 20°C (pH 6.61 to 6.79)

Description of key information

Solubility in water (OECD 105, flask method): 12 mg/L at 20°C

Key value for chemical safety assessment

Water solubility:

12 mg/L

at the temperature of:

20 °C

Additional information

The water solubility of the test item was determined compliant with GLP according to OECD guideline no. 105 and EU test method A.6 with the flask method. Incubation was performed over 24 h, 48 h and 72 h at 30 °C (n= 2 for each time period) followed by equilibration at 20 °C for 24 hours. Even after centrifugation samples were slightly turbid. Therefore, filtration over nylon (0.20 µm) filter was performed before determination of concentration by carbon analysis (TOC). The relative standard deviation (repeatability) of the concentrations over all six samples was smaller than 15 % and the three duplicate sets of samples (incubation time at 30 °C: 24 h; 48 h; and 72 h) showed no tendency of increasing concentration values over time. Thus the test was satisfactory.

Result:

Solubility in water (OECD 105, flask method; Aqura, 2010): 12 mg/L at 20°C (pH 6.61 to 6.79)