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Diss Factsheets
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EC number: 200-064-1 | CAS number: 50-78-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Two reliability 2 publications and one supporting reliability 2 company study are available, and supported by a number of data cited in one of publications. Only one publication (Marques et al. 2004) and the company study, report for pH controls. The EC50 48h obtained with pH neutralized has therefore been selected for freshwater. Only one marine water species has been assessed, without precision about pH, but evertheless selected as reliable result by weight of evidence.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 1 290 mg/L
Marine water invertebrates
Marine water invertebrates
- Effect concentration:
- 380 mg/L
Additional information
Marques et al. 2004, have reported an EC50 48h in Daphnia magna for a study performed according to OECD guideline (version 1992), based on acetylsalicylic acid test solutions prepared fom a stock solution neutralized to pH 6 to 9. The EC50 24h reported by the company study were obtained from both neutralized and non-neutralized solutions: > 1000 and 330 mg/L respectively. These results support the EC50 48h by Marques et al. 2004. Marques et al. 2004 reported also that after 48 h, the EC50 for another species: Daphnia longispina, tested in parallel, (647.31 mg/L) was about half that determined for D. magna (1293.05 mg/L), though this was not a statistically significant difference once D. magna CL included the D.longispina EC50 value. So the D. magna EC50 was retained as key value.
No other study reports for pH controls. So toxicity observed cannot be attributed to both effects of acidity and substance toxicity, or substance toxicity alone. These EC50 range from 88 to 1470 mg/L in Daphnia magna. Cyst-based toxicity tests (in Brachionus calyciflorus and Streptocephalus proboscideus in freswater, and Artemia salina in marine water) confirmed the above values for the neutralized substance. Therefore the marine water EC50 was retained, despite lack on information on pH.
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