Registration Dossier

Administrative data

Key value for chemical safety assessment

Additional information

L-tryptophan has been tested in vitro in several studies according to recent guidelines with GLP compliance:

OECD Guideline 471 (Bacterial Reverse Mutation Assay)

OECD Guideline 473 (In vitro Mammalian Chromosome Aberration Test)

OECD Guideline 476 (In vitro Mammalian Cell Gene Mutation Test)

In all of these tests negative results were obtained.

L-tryptophan has also been tested negative in vivo assays.


Short description of key information:
Genetic toxicity:
- in vitro: negative (OECD 471); negative (OECD 473); negative (OECD 476)

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

Due to the negative results obtained in studies both in vitro and in vivo, no classification according to EU and GHS criteria is required.