Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-795-6 | CAS number: 73-22-3
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Peer reviewed publications
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- L-Tryptophan: Basic Metabolic Functions, Behavioral Research and Therapeutic Indications
- Author:
- Richard DM, Dawes MA, Mathias CW, Acheson A, Hill-Kapturczak N & Dougherty DM
- Year:
- 2 009
- Bibliographic source:
- Int J Tryptophan Res 2, 45–60
- Reference Type:
- review article or handbook
- Title:
- Environmental, Toxicological, and Related Aspects of Tryptophan Metabolism with Particular Reference to the Central Nervous System
- Author:
- Curzon G, Knott PJ & Golberg L
- Year:
- 1 977
- Bibliographic source:
- Crit Rev Toxicol 5, 145-187
- Reference Type:
- publication
- Title:
- Urinary excretion of tryptophan metabolites in the healthy infant
- Author:
- Vassella F, Hellström B & Wengle B
- Year:
- 1 962
- Bibliographic source:
- Pediatrics 30, 585-591
- Reference Type:
- publication
- Title:
- Tryptophan metabolism in depression
- Author:
- Curzon G & Bridges PK
- Year:
- 1 970
- Bibliographic source:
- J Neurol Neurosurg Psychiat 33, 698-704
Materials and methods
Test material
- Reference substance name:
- L-tryptophan
- EC Number:
- 200-795-6
- EC Name:
- L-tryptophan
- Cas Number:
- 73-22-3
- Molecular formula:
- C11H12N2O2
- IUPAC Name:
- L-tryptophan
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- L-tryptophan is an essential amino acid, which cannot be synthesized in the human body and must be supplied by the diet. Only the L-isomer is used in protein synthesis and can pass across the blood-brain barrier. In humans, tryptophan has relatively low tissue storage and the overall tryptophan concentration in the body is the lowest among all amino acids. The typical intake for humans is calculated with about 900-1000 mg per day and known common sources of tryptophan are bananas, milk, tuna fish, cheese, bread, chicken, turkey, peanuts, and chocolate.
Tryptophan plays a significant role for a multitude of metabolic functions and processes (e.g. syntheses of protein, serotonin, melatonin and NAD/NADP).
Tryptophan is the sole precursor of serotonin and is distributed throughout the human body in the circulatory system (about 75-85% of tryptophan is bound to albumin). Primarily, the non-bound tryptophan is available for transport across the blood-brain barrier. The availability of tryptophan for the synthesis of brain serotonin can be affected by dietary factors.
After uptake and metabolism, tryptophan is mainly excreted via urine and as metabolites kynurenine, kynurenic acid, 3-hydroxykynurenine, 3-hydroxyanthranilic acid, and xanthurenic acid can be determined. - Executive summary:
L-tryptophan is an essential amino acid, which cannot be synthesized in the human body and must be supplied by the diet. Only the L-isomer is used in protein synthesis and can pass across the blood-brain barrier. In humans, tryptophan has relatively low tissue storage and the overall tryptophan concentration in the body is the lowest among all amino acids. The typical intake for humans is calculated with about 900-1000 mg per day and known common sources of tryptophan are bananas, milk, tuna fish, cheese, bread, chicken, turkey, peanuts, and chocolate.
Tryptophan plays a significant role for a multitude of metabolic functions and processes (e.g. syntheses of protein, serotonin, melatonin and NAD/NADP).
Tryptophan is the sole precursor of serotonin and is distributed throughout the human body in the circulatory system (about 75-85% of tryptophan is bound to albumin). Primarily, the non-bound tryptophan is available for transport across the blood-brain barrier. The availability of tryptophan for the synthesis of brain serotonin can be affected by dietary factors.
After uptake and metabolism, tryptophan is mainly excreted via urine and as metabolites kynurenine, kynurenic acid, 3-hydroxykynurenine, 3-hydroxyanthranilic acid, and xanthurenic acid can be determined.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
