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Ecotoxicological information

Short-term toxicity to fish

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Description of key information

The calculation via ECOSAR yielded 96 h LC50 values >850 mg/L.

Key value for chemical safety assessment

Additional information

According to REACH Regulation (Annex VIII, 9.1.3, column 2), the study on the acute toxicity to fish does not need to be done if aquatic toxicity is unlikely. Based on the available experimental toxicity data for daphnids (48 h LC50>100 mg/L) and algae (72 h EC50>100 mg/L) it is to be expected that the acute toxicity of L-tryptophan to fish will be low as well. This assumption is supported by calculation. The estimation of the acute toxicity to fish by ECOSAR v1.00 predicted a 96 h LC50=31000 mg/L for the aliphatic amine-acid structure, a 96 h LC50=850 mg/L for the pyrazole/pyrrole-acid structure and a 96 h LC50=83600 mg/L for the baseline toxicity (neutral organic SAR). Based on the experimental data for daphnids and algae and the estimated acute toxicity values the need for the performance of a fish, acute toxicity test is not indicated.