Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Link to relevant study record(s)

Description of key information

Short description of key information on bioaccumulation potential result: 
Di-2-EHTDG is predicted to be bioavailable via the oral route but is very poorly absorbed via skin.
Di-2-EHTDG is expected to undergo stepwise hydrolysis of the ester bonds yielding thiodiglycolic acid (TDGA; CAS: 123-93-3) and 2-ethyl-1-hexanol (2-EH; CAS: 104-76-7). Both substances are very polar and thus subject to renal elimination. Tissue accumulation can be excluded.

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential
Absorption rate - oral (%):
Absorption rate - dermal (%):
Absorption rate - inhalation (%):

Additional information


Oral absorption of Di-2-EHTDG is predicted to be high. The Danish EPA (% G.I. abs. for 1 mg dose) predicts an oral absorption of 100% following a dose of 1 mg.

The EpiSuite DermWin v2.02 program predicts a very low dermal absorption of 0.00003 mg/cm²/event.

The inhalative absorption can be neglected due to the very low vapour pressure of the substance.


The substance will be hydrolysed; the hydrolysis products are water soluble and are predicted to have no accumulation potential. They are expected to enter the urine shortly after systemic absorption.


Di-2-EHTDG will undergo enzymatic and non-enzymatic ester hydrolysis. This is a stepwise process and mixed hydrolysis and oxidation products are likely to occur at least as intermediate metabolites.

The resulting molecules, TDGA and 2-EH, are soluble in water. Both substances can be further oxidised [R2S to R2S(=O)2; -CH2OH to -COOH]. Carboxylic acids can be subject to glucuronidation (mediated by UGT isozymes) prior to urinary excretion.


The hydrolysis products of Di-2-EHTDG as well as the oxidised metabolites are soluble in water (TDGA: 317 g/L; 2-EH: 1 g/L, 2-ethylhexanoic acid: 1.1 g/L) and will be excreted rapidly via urine, either as such or as conjugates with glucuronic acid. Significant faecal excretion is not expected.