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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Remarks:
Comparable to guideline study, predates GLP, very limited reporting, but acceptable for assessment.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1977
Report date:
1977

Materials and methods

Principles of method if other than guideline:
Single dose of 2000 mg/kg bw of the test substance was applied to pre-moistened hair-clipped skin of each of the 6 rabbits under occlusive dressing. The patch was removed 24 hours post-dosing and animals were observed for 7 days.
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Zinc bis(diethyldithiocarbamate)
EC Number:
238-270-9
EC Name:
Zinc bis(diethyldithiocarbamate)
Cas Number:
14324-55-1
Molecular formula:
C10H20N2S4Zn
IUPAC Name:
zinc bis(diethyldithiocarbamate)
Details on test material:
- Name of test material (as cited in study report): Ethyl Ziram (WTR 38)
- Physical state: White powder

Test animals

Species:
rabbit
Strain:
other: albino
Sex:
not specified

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
TEST SITE
- Area of exposure: trunk
- Type of wrap if used: Covered with a two-ply layer of wet gauze and overcovered with an empervious sleeve.
Duration of exposure:
24 hours
Doses:
Single dose: 2000 mg/kg
No. of animals per sex per dose:
6 animals
Control animals:
no
Details on study design:
- Duration of observation period following administration: 7 days

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Mortality:
None.
Clinical signs:
other: other: All animals remaind asymptomatic during the observation period.
Gross pathology:
No data.

Applicant's summary and conclusion