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EC number: 274-713-2 | CAS number: 70643-20-8
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
[14C]-2,4-diaminophenoxyethanol dihydrochloride in oxidative and non oxidative test preparations was applied topically to human skin in vitro. Under the present experimental conditions, for [14C]-2,4-diaminophenoxyethanol dihydrochloride in the oxidative test preparation, most of the applied dose was removed at 30 min post dose (88.4% of the applied dose). At 24 h post dose, a further 1.3% was removed, therefore, the dislodgeable dose was 89.78% of the applied dose. At 24 h post dose, the absorbed dose and dermal delivery were 0.03% (0.11 μg equiv/cm2) and 0.41% (1.74 μg equiv/cm2) of the applied dose, respectively. Under the present experimental conditions, for [14C]-2,4-diaminophenoxyethanoldihydrochloride in the non oxidative test preparation, most of the applied dose was removed at 30 min post dose (92.2% of the applied dose). At 24 h post dose, a further 2.0% was removed, therefore, the dislodgeable dose was 94.2% of the applied dose. At 24 h post dose, the absorbed dose and dermal delivery were 0.75% (2.94 μg equiv/cm2) and 1.68% (6.55 μg equiv/cm2) of the applied dose, respectively. The amounts of 2,4-diaminophenoxyethanol dihydrochloride considered as absorbed from a typical oxidative hair colouring mixture containing 2,4-diaminophenoxyethanol dihydrochloride at a final concentration of 2.0% were estimated to be 1.74 ± 1.08 μg/cm2 (0.38 – 4.33 μg/cm2). The amounts of 2,4-diaminophenoxyethanol dihydrochloride considered as absorbed from a non-oxidative mixture containing 2,4-diaminophenoxyethanol dihydrochloride at a final concentration of 2.0% were estimated to be 6.55 ± 4.72 μg/cm2 (1.56 – 16.61 μg/cm2). However, the maximum dermal absorption of 4.33 μg equiv/cm² (1.10% absorption rate), observed under oxidative conditions in a typical hair dye formulation, which had been used for the calculation of the margin of safety according to SCCS opinion.
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
- Absorption rate - dermal (%):
- 1.1
Additional information
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