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EC number: 202-452-6 | CAS number: 95-79-4
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- sub-chronic toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Reference Type:
- secondary source
- Title:
- BUA Stoffbericht 55: Chlortoluidine (3-Chlor-2-methylanilin, 5-Chlor-2-methylanilin, 3-Chlor-4-methylanilin)
- Author:
- BUA Beratergremium für umweltrelevante Altstoffe
- Year:
- 1 990
- Bibliographic source:
- Verlag Chemie Weinheim 1991
Materials and methods
Test guideline
- Guideline:
- other: no data
- Principles of method if other than guideline:
- see BUA Stoffberichte No. 55 for details
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 5-chloro-o-toluidine
- EC Number:
- 202-452-6
- EC Name:
- 5-chloro-o-toluidine
- Cas Number:
- 95-79-4
- Molecular formula:
- C7H8ClN
- IUPAC Name:
- 5-chloro-2-methylaniline
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 4 weeks
- Frequency of treatment:
- no data
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
31.5 mg/kg BW
Basis:
nominal in diet
- Remarks:
- Doses / Concentrations:
68 mg/kg BW
Basis:
nominal in diet
- Remarks:
- Doses / Concentrations:
146.5 mg/kg BW
Basis:
nominal in diet
- Remarks:
- Doses / Concentrations:
315.5 mg/kg BW
Basis:
nominal in diet
- Remarks:
- Doses / Concentrations:
680 mg/kg BW
Basis:
nominal in diet
- No. of animals per sex per dose:
- 5
Results and discussion
Results of examinations
- Clinical signs:
- no effects observed
- Description (incidence and severity):
- No mortallity. 100 % of the animals survived.
- Mortality:
- no mortality observed
- Description (incidence):
- No mortallity. 100 % of the animals survived.
- Body weight and weight changes:
- effects observed, treatment-related
- Description (incidence and severity):
- reduced weight increase rate
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- effects observed, treatment-related
- Description (incidence and severity):
- speckled liver and kidneys even at lowest concentration
- Histopathological findings: non-neoplastic:
- no effects observed
- Histopathological findings: neoplastic:
- no effects observed
Effect levels
- Remarks on result:
- not measured/tested
- Remarks:
- Effect level not specified (migrated information)
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
The study was conducted as a preliminary test to determine the optimal dosage for a chronic toxicity study. Therefore no effect level is available.
Applicant's summary and conclusion
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