Registration Dossier
Registration Dossier
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EC number: 202-452-6 | CAS number: 95-79-4
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline Study, GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- GLP compliance:
- no
Test material
- Reference substance name:
- 5-chloro-o-toluidine
- EC Number:
- 202-452-6
- EC Name:
- 5-chloro-o-toluidine
- Cas Number:
- 95-79-4
- Molecular formula:
- C7H8ClN
- IUPAC Name:
- 5-chloro-2-methylaniline
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- Himalayan
Test system
- Vehicle:
- other: Sesam oil and no vehicle
- Amount / concentration applied:
- 0,1 ml
- Observation period (in vivo):
- 14 days
- Number of animals or in vitro replicates:
- 6
Results and discussion
Any other information on results incl. tables
After conjunctival application of 0.1 ml 5 - chloro-o-toluidin slight redding and swelling was observed. The cornea showed clouding up to seven days. All irritations were reversible within 14 days.
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: US CPSC / US FDA
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