Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline Study, GLP

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1976

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
5-chloro-o-toluidine
EC Number:
202-452-6
EC Name:
5-chloro-o-toluidine
Cas Number:
95-79-4
Molecular formula:
C7H8ClN
IUPAC Name:
5-chloro-2-methylaniline

Test animals / tissue source

Species:
rabbit
Strain:
Himalayan

Test system

Vehicle:
other: Sesam oil and no vehicle
Amount / concentration applied:
0,1 ml
Observation period (in vivo):
14 days
Number of animals or in vitro replicates:
6

Results and discussion

Any other information on results incl. tables

After conjunctival application of 0.1 ml 5 - chloro-o-toluidin slight redding and swelling was observed. The cornea showed clouding up to seven days. All irritations were reversible within 14 days.

Applicant's summary and conclusion

Interpretation of results:
irritating
Remarks:
Migrated information Criteria used for interpretation of results: US CPSC / US FDA