5-chloro-o-toluidine

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Original Report not available.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1976

Materials and methods

Test guideline

Guideline:

other: no data

GLP compliance:

no

Test type:

acute toxic class method

Test material

Test material information

Constituent 1

Reference substance name:

5-chloro-o-toluidine

EC Number:

202-452-6

EC Name:

5-chloro-o-toluidine

Cas Number:

95-79-4

Molecular formula:

C7H8ClN

IUPAC Name:

5-chloro-2-methylaniline

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

other: sesame oil

Results and discussion

Effect levels

Effect levels 1

Sex:

female

Dose descriptor:

LD50

Effect level:

716 mg/kg bw

Based on:

test mat.

95% CL:

>= 646 - <= 793

Effect levels 2

Sex:

male

Dose descriptor:

LD50

Effect level:

632 mg/kg bw

Based on:

test mat.

95% CL:

>= 551 - <= 726