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EC number: 942-100-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- March 22, 1973
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- not applicable
- GLP compliance:
- no
- Remarks:
- Pre GLP.
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Reaction products of copper phthalocyanine, sulfuric acid, and sodium carbonate
- EC Number:
- 942-100-5
- Molecular formula:
- Not applicable: UVCB substance
- IUPAC Name:
- Reaction products of copper phthalocyanine, sulfuric acid, and sodium carbonate
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: ARS/Sprague - Dawley, Madison, Winsconsin
- Age at study initiation:
- Weight at study initiation: 153 g
- Fasting period before study: fasted during exposition
- Housing: individually in stock cages
- Diet (e.g. ad libitum): standard laboratory diet with Purina Rat Chow, Ralston Purina Company, St. louis, Missouri
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 23°C
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- whole body
- Vehicle:
- clean air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: Plexiglass inhalation chamber
- Exposure chamber volume: 70 liters
- Method of holding animals in test chamber:
- Source and rate of air: Dust feeder, rate of air: 6.4 L/min
- Method of particle size determination: microscopic determination
- Temperature, humidity, pressure in air chamber: 25 °C, 29.92 inches Hg
TEST ATMOSPHERE
- Samples taken from breathing zone: yes
TEST ATMOSPHERE (if not tabulated)
- Particle size distribution: 1 - 5 microns : 34%; 6 - 25 microns: 58%; 26 - 615 microns: 8% - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- ca. 4 h
- Concentrations:
- 179 mg/m3 air
- No. of animals per sex per dose:
- 5 male and 5 female
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: body weight
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 179 mg/m³ air (analytical)
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- No deaths occurred
- Clinical signs:
- other: No evidence
- Body weight:
- Within the normal limits, average two-week body weight gain was 57g
- Gross pathology:
- Minimal to mild focal red discoloration of the lungs in all rats
- Other findings:
- No untoward behavioral reactions
Any other information on results incl. tables
Particle Size Distribution data:
Particle size range (microns) |
N. of Particles counted | % of total counted |
1 - 5 | 152 | 34 |
6 - 25 | 263 | 58 |
26 - 615 | 35 | 8 |
Applicant's summary and conclusion
- Conclusions:
- LC50 (male/female) > 179 mg/m3 air
- Executive summary:
The substance to be registered has been tested according a procedure similar to OECD 403. During the study the concentration of 179 mg/m3 air has been tested on ten rats (5 male and 5 female). After the 14 days observation period there were no deaths, no untoward behavioural reactions or adverse body weight effect. Necroscopy revealed minimal to mild red discoloration in the lungs of all rats. In these experimental conditions the test substance has shown a LC50 > 179 mg/m3 air.
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