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EC number: 941-899-8 | CAS number: -
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1974
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Justification for type of information:
- None
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Principles of method if other than guideline:
- The test was done at Ciba-Geigy internal labs according to a standard SOP comparable to OECD 203 as of today before any international guidelines have been established.
- GLP compliance:
- no
- Specific details on test material used for the study:
- None
- Analytical monitoring:
- no
- Details on sampling:
- No data
- Vehicle:
- no
- Details on test solutions:
- No data
- Test organisms (species):
- other: Fish (Trout)
- Details on test organisms:
- No data
- Test type:
- not specified
- Water media type:
- not specified
- Limit test:
- no
- Total exposure duration:
- 48 h
- Post exposure observation period:
- No data
- Hardness:
- No data
- Test temperature:
- 14 °C
- pH:
- 7.4 to 8.2
- Dissolved oxygen:
- No data
- Salinity:
- No data
- Nominal and measured concentrations:
- 2, 20, 100, 200 and 1000 mg/l
- Details on test conditions:
- No data
- Reference substance (positive control):
- not specified
- Duration:
- 48 h
- Dose descriptor:
- LC0
- Effect conc.:
- 200 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Key result
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 450 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 48 h
- Dose descriptor:
- LC100
- Effect conc.:
- 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- None
- Results with reference substance (positive control):
- No data
- Reported statistics and error estimates:
- No data
- Sublethal observations / clinical signs:
None
- Validity criteria fulfilled:
- yes
- Conclusions:
- 48 h LC50 for FAT 40065/A is found to be 450 mg/l in trout fish.
- Executive summary:
48 h LC50 for FAT 40065/A is found to be 450 mg/l in trout fish.
LC 0 = 200 mg/l
LC100 = 1000 mg/l
Reference
Description of key information
The LC50 to trout was 450 mg/L.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 450 mg/L
Additional information
8 Rainbow trouts per test concentration have been tested in a pre-guideline test comparable to OECD 203 for acute fish toxicity. test reports done with test item FAT 40065/A are available. The nominal concentrations of FAT 40046/A tested were 2, 20, 100, 200 and 1000 mg/L. Additionally, a blank control without test item was carried out. The duration of the test was 48 hours. Based on the mortality occurred the following LC-values have been defined. Additional toxicity data beyond mortality have not been reported.
LC0 after 48 h was 200 mg/L, the LC50 was 450 mg/L (graphically determined) and LC100 after 48 h was 1000 mg/L.
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