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Ecotoxicological information

Short-term toxicity to fish

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Reference
Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1974
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions
Justification for type of information:
None
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 203 (Fish, Acute Toxicity Test)
Principles of method if other than guideline:
The test was done at Ciba-Geigy internal labs according to a standard SOP comparable to OECD 203 as of today before any international guidelines have been established.
GLP compliance:
no
Specific details on test material used for the study:
None
Analytical monitoring:
no
Details on sampling:
No data
Vehicle:
no
Details on test solutions:
No data
Test organisms (species):
other: Fish (Trout)
Details on test organisms:
No data
Test type:
not specified
Water media type:
not specified
Limit test:
no
Total exposure duration:
48 h
Post exposure observation period:
No data
Hardness:
No data
Test temperature:
14 °C
pH:
7.4 to 8.2
Dissolved oxygen:
No data
Salinity:
No data
Nominal and measured concentrations:
2, 20, 100, 200 and 1000 mg/l
Details on test conditions:
No data
Reference substance (positive control):
not specified
Duration:
48 h
Dose descriptor:
LC0
Effect conc.:
200 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Key result
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
450 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Duration:
48 h
Dose descriptor:
LC100
Effect conc.:
1 000 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Details on results:
None
Results with reference substance (positive control):
No data
Reported statistics and error estimates:
No data

None

Validity criteria fulfilled:
yes
Conclusions:
48 h LC50 for FAT 40065/A is found to be 450 mg/l in trout fish.
Executive summary:

48 h LC50 for FAT 40065/A is found to be 450 mg/l in trout fish.

LC 0 = 200 mg/l

LC100 = 1000 mg/l

Description of key information

The LC50 to trout was 450 mg/L.

Key value for chemical safety assessment

LC50 for freshwater fish:
450 mg/L

Additional information

8 Rainbow trouts per test concentration have been tested in a pre-guideline test comparable to OECD 203 for acute fish toxicity. test reports done with test item FAT 40065/A are available. The nominal concentrations of FAT 40046/A tested were 2, 20, 100, 200 and 1000 mg/L. Additionally, a blank control without test item was carried out. The duration of the test was 48 hours. Based on the mortality occurred the following LC-values have been defined. Additional toxicity data beyond mortality have not been reported.

LC0 after 48 h was 200 mg/L, the LC50 was 450 mg/L (graphically determined) and LC100 after 48 h was 1000 mg/L.