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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to fish

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1974
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions
Justification for type of information:
None
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 203 (Fish, Acute Toxicity Test)
Principles of method if other than guideline:
The test was done at Ciba-Geigy internal labs according to a standard SOP comparable to OECD 203 as of today before any international guidelines have been established.
GLP compliance:
no
Specific details on test material used for the study:
None
Analytical monitoring:
no
Details on sampling:
No data
Vehicle:
no
Details on test solutions:
No data
Test organisms (species):
other: Fish (Trout)
Details on test organisms:
No data
Test type:
not specified
Water media type:
not specified
Limit test:
no
Total exposure duration:
48 h
Post exposure observation period:
No data
Hardness:
No data
Test temperature:
14 °C
pH:
7.4 to 8.2
Dissolved oxygen:
No data
Salinity:
No data
Nominal and measured concentrations:
2, 20, 100, 200 and 1000 mg/l
Details on test conditions:
No data
Reference substance (positive control):
not specified
Duration:
48 h
Dose descriptor:
LC0
Effect conc.:
200 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Key result
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
450 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Duration:
48 h
Dose descriptor:
LC100
Effect conc.:
1 000 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Details on results:
None
Results with reference substance (positive control):
No data
Reported statistics and error estimates:
No data
Sublethal observations / clinical signs:

None

Validity criteria fulfilled:
yes
Conclusions:
48 h LC50 for FAT 40065/A is found to be 450 mg/l in trout fish.
Executive summary:

48 h LC50 for FAT 40065/A is found to be 450 mg/l in trout fish.

LC 0 = 200 mg/l

LC100 = 1000 mg/l

Description of key information

The LC50 to trout was 450 mg/L.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
450 mg/L

Additional information

8 Rainbow trouts per test concentration have been tested in a pre-guideline test comparable to OECD 203 for acute fish toxicity. test reports done with test item FAT 40065/A are available. The nominal concentrations of FAT 40046/A tested were 2, 20, 100, 200 and 1000 mg/L. Additionally, a blank control without test item was carried out. The duration of the test was 48 hours. Based on the mortality occurred the following LC-values have been defined. Additional toxicity data beyond mortality have not been reported.

LC0 after 48 h was 200 mg/L, the LC50 was 450 mg/L (graphically determined) and LC100 after 48 h was 1000 mg/L.