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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2014-08-11
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Justification for type of information:
None
Qualifier:
according to
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Qualifier:
according to
Guideline:
EU Method A.4 (Vapour Pressure)
GLP compliance:
yes (incl. certificate)
Type of method:
effusion method: by loss of weight or by trapping vaporisate
Remarks:
Isothermal Thermogravimetry
Specific details on test material used for the study:
None
Key result
Temp.:
20 °C
Vapour pressure:
<= 0 Pa

Results:

Due to test item properties (water content ≤ 10 % (w/w)) the sample for the measurement was dried at 150 °C.

The experiment was done applying temperatures from 170 °C to 220 °C.

The regression curve for calibration is: The coefficient of correlation (r2) was 0.9981.


Extrapolation of the curve to 20 °C and fitting this value in the regression curve, a vapour pressure of 1.32 × 10-7Pa was obtained (mean of three determinations).

Conclusions:
The vapour pressure of the test item at 20 °C (293K) was: 1.32E-7 Pa.
Executive summary:

The vapour pressure of the test item was determined based on the procedures indicated by the following internationally accepted methods: - OECD Guideline 104 and - EU Method A.4.

The isothermal thermogravimetrical effusion method was used for this purpose. The evaporation rates at 20 °C of the reference items were used to establish a regression log vapour pressure versus log evaporation rate. From this regression the vapour pressure of the test item was calculated based on the determined evaporation rate.

As a result of the non GLP pre-tests, the main test was done above 170 °C and below 220 °C. The drying phase was carried out at 150 °C for 20 min. The test was carried out on three replicates, with the starting temperature of minimum 170 °C. The temperature is then increased by minimum 10 °C after every isothermal interval of 5 minutes. The end temperature was 220 °C.

Based on the findings of the study, the vapour pressure of the test item at 20 °C (293K) was calculated to be: 1.32 × 10-7 Pa (mean of three determinations, without water).

Description of key information

The vapour pressure of the test item at 20 °C (293K) was calculated to be:1.32 × 10-7 Pa.

Key value for chemical safety assessment

Vapour pressure:
0 Pa
at the temperature of:
20 °C

Additional information

The vapour pressure of the test itemwas determined based on the procedures indicated by the following internationally accepted methods: - OECD Guideline 104and- EU Method A.4.

The isothermal thermogravimetrical effusion method was used for this purpose.The evaporation rates at 20 °C of the reference items were used to establish a regression log vapour pressure versus log evaporation rate. From this regression the vapour pressure of the test item was calculated based on the determined evaporation rate.

As a result of the non GLP pre-tests, the main test was done above 170 °C and below 220 °C.The drying phase was carried out at 150 °C for 20 min. The test was carried out on three replicates, with the starting temperature ofminimum 170 °C. The temperature is then increased by minimum 10 °C after every isothermal interval of 5 minutes. The end temperature was 220 °C.

Based on the findings of the study, the vapour pressure of the test item at 20 °C (293K) was calculated to be:1.32 × 10 -7 Pa (mean of three determinations, without water).