hexasodium 4-[3-(2-bromoprop-2-enamido)benzamido]-6-[(E)-2-[5-(2,3-dibromopropanamido)-2-sulfophenyl]diazen-1-yl]-5-hydroxynaphthalene-1,7-disulfonate 6-[(E)-2-[5-(2-bromoprop-2-enamido)-2-sulfophenyl]diazen-1-yl]-4-[3-(2-bromoprop-2-enamido)benzamido]-5-hydroxynaphthalene-1,7-disulfonate

Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2014-08-11

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

None

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

GLP compliance:

yes (incl. QA statement)

Type of method:

effusion method: by loss of weight or by trapping vaporisate

Remarks:

Isothermal Thermogravimetry

Specific details on test material used for the study:

None

Key result

Temp.:

20 °C

Vapour pressure:

<= 0 Pa

Results:

Due to test item properties (water content ≤ 10 % (w/w)) the sample for the measurement was dried at 150 °C. The experiment was done applying temperatures from 170 °C to 220 °C. The regression curve for calibration is: The coefficient of correlation (r^2) was 0.9981. Extrapolation of the curve to 20 °C and fitting this value in the regression curve, a vapour pressure of 1.32 × 10^-7Pa was obtained (mean of three determinations).

Conclusions:

The vapour pressure of the test item at 20 °C (293K) was: 1.32E-7 Pa.

Executive summary:

The vapour pressure of the test item was determined based on the procedures indicated by the following internationally accepted methods: - OECD Guideline 104 and - EU Method A.4.

The isothermal thermogravimetrical effusion method was used for this purpose. The evaporation rates at 20 °C of the reference items were used to establish a regression log vapour pressure versus log evaporation rate. From this regression the vapour pressure of the test item was calculated based on the determined evaporation rate.

As a result of the non GLP pre-tests, the main test was done above 170 °C and below 220 °C. The drying phase was carried out at 150 °C for 20 min. The test was carried out on three replicates, with the starting temperature of minimum 170 °C. The temperature is then increased by minimum 10 °C after every isothermal interval of 5 minutes. The end temperature was 220 °C.

Based on the findings of the study, the vapour pressure of the test item at 20 °C (293K) was calculated to be: 1.32 × 10^-7 Pa (mean of three determinations, without water).

Description of key information

The vapour pressure of the test item at 20 °C (293K) was calculated to be:1.32 × 10^-7 Pa.

Key value for chemical safety assessment

Vapour pressure:

0 Pa

at the temperature of:

20 °C

Additional information

The vapour pressure of the test itemwas determined based on the procedures indicated by the following internationally accepted methods: - OECD Guideline 104and- EU Method A.4.

The isothermal thermogravimetrical effusion method was used for this purpose.The evaporation rates at 20 °C of the reference items were used to establish a regression log vapour pressure versus log evaporation rate. From this regression the vapour pressure of the test item was calculated based on the determined evaporation rate.

As a result of the non GLP pre-tests, the main test was done above 170 °C and below 220 °C.The drying phase was carried out at 150 °C for 20 min. The test was carried out on three replicates, with the starting temperature ofminimum 170 °C. The temperature is then increased by minimum 10 °C after every isothermal interval of 5 minutes. The end temperature was 220 °C.

Based on the findings of the study, the vapour pressure of the test item at 20 °C (293K) was calculated to be:1.32 × 10 ^-7 Pa (mean of three determinations, without water).