Registration Dossier
Registration Dossier
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EC number: 255-501-9 | CAS number: 41687-30-3
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- other: Authoritative data base
- Title:
- HSDB Number : 645
- Year:
- 2 012
- Bibliographic source:
- HSDB (Hazardous Substances Data Bank); Kirk-Othmer Encyclopedia of Chemical Technology. 4th ed. Volumes 1: New York, NY. John Wiley and Sons, 1991-Present., (95) 727
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- HSDB database
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- Linalool
- EC Number:
- 201-134-4
- EC Name:
- Linalool
- Cas Number:
- 78-70-6
- IUPAC Name:
- 3,7-dimethylocta-1,6-dien-3-ol
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- CD-1
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- other: oily solution
- Control animals:
- yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 3 500 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Mortality occurred in the first 24 hours, regardless of vehicle used
Any other information on results incl. tables
Toxic effectsincluded hypermotility with ataxia; sedation or depression following the doses; and dyspnea before death.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Executive summary:
Linalol (CAS # 78-70-6) was evaluated for acute oral toxicity. The test substance wasadministered to CD1 mice (4/sex/solution) at 5 dose levels. The LD50 is approximately3.5 g/kg (oily solution). Toxic effectsincluded hypermotility with ataxia; sedation or depression following the doses; anddyspnea before death. Mortality occurred in the first 24 hours, regardless of vehicleused
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