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Short-term toxicity to fish

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Description of key information

96 hr LC50 (mortality) = 21 mg/L

Key value for chemical safety assessment

LC50 for freshwater fish:
21 mg/L

Additional information

Since no short-term fish studies are available for C9AS Na (CAS 1072-15-7), in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 a read across to other structurally related category member was conducted. Read-across data from pure homologues C8AS Na (CAS 142-31-4) and C10AS Na (CAS 142-87-0) were used. As the toxicity of alkyl sulfates is dependent on the carbon chain length, it is expected that the toxicity of C9 homologue will be lower than the toxicity of C10 homologue and higher than of C8 homologue.

GLP study was performed with C8AS Na (CAS 142-31-4) according to OECD 203 guideline (Neven 1993). Zebrafish (Danio rerio) were exposed for 96 hours to five test concentrations up to 100 mg/L (nominal concentrations in agreement with the measured ones). Since no toxic effects were observed up to the highest test concentration, the 96-hour LC50 value was determined above 100 mg/L (nominal concentration).

Moreover, three reliable short-term studies with fish are available for C10AS Na (CAS 142-87-0). In the non-GLP study performed according to Japanese Industrial Standard JIS K0102, 1-week old carp pre-larvae (Cyprinus carpio) were exposed to C10AS Na for 48 hours under static conditions (Kikuchi et al. 1976a). Based on pre-larvae mortality, the LC50 value was 13 mg/L (nominal concentrations in agreement with the measured ones). Since the obtained value was the most critical, it is considered as a reliable short-term LC50 value for fish for C10AS Na (CAS 142-87-0). The same authors provide information on Carp egg hatching rate influenced by C10AS Na (Kikuchi 1976b). Fish eggs were exposed for 96 hours to the test concentrations up to 100 mg/L (nominal concentrations in agreement with the measured ones). The study followed Japanese Industrial Standard JIS K0102. Inhibition of hatching rate could not be calculated because hatching rate was higher at 70 mg/L (ca. 40%) than at 50 mg/L (ca. 12%). No hatching at 100 mg/L was observed. Hatching rate in the control group was 87.3%. Another non-GLP study performed according to ISO 7346-1 guidance is available (Richterich 2001). Mortality of zebrafish (Danio rerio) was determined after 24, 48, 72 and 96 hours of exposure to five test concentrations up to 1000 mg/L of product containing 30% of active ingredient and 70% water (nominal concentrations). Analytical monitoring was not performed. The results showed that the 96-hour LC50 value was 177 mg a.i./L (nominal concentration).

Due to structural and property similarities with the tested category member, it can be concluded that the above results apply also to C9AS Na (CAS 1072-15-7). The short-term LC50 value for fish will be above 13 mg/L. Using the additivity formula stipulated in the EC Regulation 1272/2008, the LC50 value for C9AS Na (CAS 1072-15-7) calculated based on toxicities of C8AS Na (CAS 142-31-4) and C10AS Na (CAS 142-87-0) is 21 mg/L.