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Diss Factsheets
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EC number: 424-090-1 | CAS number: 10097-02-6 DMBA
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Hydrolysis
The study of determination of Hydrolysis as a Function of pH was performed as a preliminary test according to 92/69/EEC, C7 (OECD 111). The substance was found to be hydrolytically stable under acidic, neutral and basic conditions.
The dissipation DT50 of parent compound was established as follow: DT50 at pH = 4 was more than 8760 hours; DT50 at pH = 7 was more than 8760 hours; DT50 at pH = 9 was more than 8760 hours.
Biodegradation
The key study was performed toOECD 301 C Modified MITI Test.The test material was tested at a concentration of 100 mg/L and the inoculum was activated sludge (mixed liquor suspended solids: 3550 mg/L). The degradation of the test substance was assessed by the determination of Biochemical oxygen demand (BOD) for 28 days and measurements of dissolved organic carbon (DOC) and residual test substance (by gas chromatography) on Day 28. The test treatment was measured in triplicate and one vessel for each of activity control (aniline + sludge + basal medium), abiotic control (test substance + deionised water) and inoculum blank (sludge + basal medium) were taken.
The average biodegradation values of DMBA were 6, 15 and 12 %, based on BOD, DOC and residual test substance, respectively. From the degradability results based on the BOD, it was concluded that the test substance is not readily biodegradable under the conditions of the modified MITI test. It was suggested that degradation of the test substance continued in one of three test vessels. Therefore, once microorganisms were acclimated and biodegradation was started, the test substance may be degraded completely without making transformed products. However, it would be required much time to degrade the test substance completely.
Bioaccumulation
According to result from QSAR study on adsorption/desorption using KOCWIN v2.00; MCI method (EPISUITE v 4.11), the substance falls within the applicability domain (2,2-bis(hydroxymethyl) butanoic acid is organic monoconstituent substance with molecular weight of 148.16) and therefore the predicted value (Koc: 10.0 L/kg, Log Koc: 1.0) can be considered as reliable taking into account the statistical information for the MCI (Molecular Connectivity Index, first-order) training and validation datasets. The predicted value was used for Chemical safety assessment (CSA) and is considered as adequate and no additional information is required.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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