Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

No indication of sensitising properties. SCCS conclude in their opinion (SCCS/1246/09): "..it must be recognised that quaternary ammonium compounds are not known to be sensitising, but merely corrosive. There are some rare clinical reports, but considering the many years of use of these compounds, they are considered to be of minor importance. Therefore there is no reason to consider cetrimonium chloride, steartrimonium chloride or behentrimonium chloride as skin sensitisers."


Migrated from Short description of key information:
SCCS evaluated this OECD 406 study to be negative. SCCS also found a Buehler test on cetrimonium chloride negative.

Justification for selection of skin sensitisation endpoint:
Data on C16 alkyltrimethylammonium chloride are used for prediction of the sensitisation of the C14 alkyltrimethylammonium bromide.
A OECD 406 (GPMT) study on cetrimonium chloride is relevant for read-across to tetradonium bromide

Justification for classification or non-classification

The substance is not considered to be a skin sensitizer according to read-across from data on cetrimonium chloride and according to the OECD QSAR Toolbox prediction.